Prospective identification and isolation of murine bone marrow derived multipotent mesenchymal progenitor cells

被引：17

作者：

Anjos-Afonso, Fernando ^{[1
]}

Bonnet, Dominique ^{[1
]}

机构：

[1] Canc Res UK, Haematopoiet Stem Cell Lab, London Res Inst, London WC2A 3PX, England

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2011年 / 24卷 / 01期

关键词：

mesenchymal stroma cell (MSC); mesenchymal progenitor cell (MPC); sca-1; multipotent differentiation; pericyte advenmial reticular cell; vascular smooth muscle cell (VSMC); ADULT STEM-CELLS; SMOOTH-MUSCLE-CELLS; STROMAL CELLS; IN-VITRO; NG2; PROTEOGLYCAN; MICROVASCULAR PERICYTES; INBRED MICE; EXPRESSION; DIFFERENTIATION; GROWTH;

D O I：

10.1016/j.beha.2010.11.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Enormous confusion still exists in the scientific community regarding the in vivo identity of putative bone marrow (BM) multipotent mesenchymal progenitor cells (MPCs). There is still lack of consensus between laboratories on this issue but recent advancements in this field have shed light on the identity of these cells in humans. However, in mice there are limited and reproducible data available that convincingly define prospectively these cells in vivo. In this review we will critically address: 1) important considerations on how to interpret MPC nomenclature, heterogeneity and differentiation abilities; 2) potential surface antigens that could aid in the isolation of MPC from mouse BM; 3) and their topography and prospective cellular relationship with pericytes, adventitial reticulocytes (ARCs) and vascular smooth muscle cells (VSMCs). (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：13 / 24

页数：12

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