Prospective identification and isolation of murine bone marrow derived multipotent mesenchymal progenitor cells

被引:17
作者
Anjos-Afonso, Fernando [1 ]
Bonnet, Dominique [1 ]
机构
[1] Canc Res UK, Haematopoiet Stem Cell Lab, London Res Inst, London WC2A 3PX, England
关键词
mesenchymal stroma cell (MSC); mesenchymal progenitor cell (MPC); sca-1; multipotent differentiation; pericyte advenmial reticular cell; vascular smooth muscle cell (VSMC); ADULT STEM-CELLS; SMOOTH-MUSCLE-CELLS; STROMAL CELLS; IN-VITRO; NG2; PROTEOGLYCAN; MICROVASCULAR PERICYTES; INBRED MICE; EXPRESSION; DIFFERENTIATION; GROWTH;
D O I
10.1016/j.beha.2010.11.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Enormous confusion still exists in the scientific community regarding the in vivo identity of putative bone marrow (BM) multipotent mesenchymal progenitor cells (MPCs). There is still lack of consensus between laboratories on this issue but recent advancements in this field have shed light on the identity of these cells in humans. However, in mice there are limited and reproducible data available that convincingly define prospectively these cells in vivo. In this review we will critically address: 1) important considerations on how to interpret MPC nomenclature, heterogeneity and differentiation abilities; 2) potential surface antigens that could aid in the isolation of MPC from mouse BM; 3) and their topography and prospective cellular relationship with pericytes, adventitial reticulocytes (ARCs) and vascular smooth muscle cells (VSMCs). (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:13 / 24
页数:12
相关论文
共 88 条
[1]   Expression of endoglin mRNA and protein in human vascular smooth muscle cells [J].
Adam, PJ ;
Clesham, GJ ;
Weissberg, PL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 247 (01) :33-37
[2]   Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung [J].
Aguilar, Susana ;
Nye, Emma ;
Chan, Jerry ;
Loebinger, Michael ;
Spencer-Dene, Bradley ;
Fisk, Nick ;
Stamp, Gordon ;
Bonnet, Dominique ;
Janes, Sam M. .
STEM CELLS, 2007, 25 (06) :1586-1594
[3]   Role of platelet-derived growth factors in physiology and medicine [J].
Andrae, Johanna ;
Gallini, Radiosa ;
Betsholtz, Christer .
GENES & DEVELOPMENT, 2008, 22 (10) :1276-1312
[4]   In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions [J].
Anjos-Afonso, F ;
Siapati, EK ;
Bonnet, D .
JOURNAL OF CELL SCIENCE, 2004, 117 (23) :5655-5664
[5]  
Anjos-Afonso F., 2008, CURR PROTOC STEM CEL
[6]   Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation [J].
Arai, F ;
Ohneda, O ;
Miyamoto, T ;
Zhang, XQ ;
Suda, T .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (12) :1549-1563
[7]   Endothelial/pericyte interactions [J].
Armulik, A ;
Abramsson, A ;
Betsholtz, C .
CIRCULATION RESEARCH, 2005, 97 (06) :512-523
[8]   Pericytes and endothelial precursor cells: Cellular interactions and contributions to malignancy [J].
Bagley, RG ;
Weber, W ;
Rouleau, C ;
Teicher, BA .
CANCER RESEARCH, 2005, 65 (21) :9741-9750
[9]   Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy [J].
Banfi, A ;
Muraglia, A ;
Dozin, B ;
Mastrogiacomo, M ;
Cancedda, R ;
Quarto, R .
EXPERIMENTAL HEMATOLOGY, 2000, 28 (06) :707-715
[10]   Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes [J].
Barbero, A ;
Ploegert, S ;
Heberer, M ;
Martin, I .
ARTHRITIS AND RHEUMATISM, 2003, 48 (05) :1315-1325