Innate lymphoid cells in atherosclerosis

被引：26

作者：

Engelbertsen, Daniel ^{[1
]}

Lichtman, Andrew H.

机构：

[1] Brigham & Womens Hosp, Dept Pathol, 77 Ave Louis Pasteur, Boston, MA 02115 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2017年 / 816卷

基金：

瑞典研究理事会;

关键词：

Innate lymphoid cells; Atherosclerosis; Inflammation; Mouse models; Cytokines; PLAQUE-FORMATION;

D O I：

10.1016/j.ejphar.2017.04.030

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions. ILC1s produce IFN-gamma upon stimulation with IL-12 and IL-18, ILC2s produce IL-5 and IL-13 responding to IL-33 and IL-25 while ILC3s produce IL-17 and IL-22 after stimulation with IL-23 or IL-1. Although few studies have directly investigated the role for ILCs in atherosclerosis, several studies have investigated transcription factors and cytokines shared by ILCs and T helper cells. In this review we summarize our current understanding of the role of ILC in atherosclerosis and discuss future directions.

引用

页码：32 / 36

页数：5

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