Protein Kinase C Isoforms in Neutrophil Adhesion and Activation

被引：57

作者：

Bertram, Anna ^{[2
]}

Ley, Klaus ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Inflammat, Div Inflammat Biol, La Jolla, CA 92037 USA

[2] Hannover Med Sch, Dept Nephrol, D-30625 Hannover, Germany

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2011年 / 59卷 / 02期

关键词：

Neutrophil; Protein kinase C; Integrin activation; Adhesion; Rolling; NADPH oxidase; SELECTIN GLYCOPROTEIN LIGAND-1; RECEPTOR-MEDIATED PHAGOCYTOSIS; CYTOPLASMIC DOMAIN; IN-VIVO; NADPH OXIDASE; POLYMORPHONUCLEAR LEUKOCYTES; LEUKEMIC NEUTROPHILS; SUSTAINED ADHESION; STRUCTURAL BASIS; OXIDATIVE BURST;

D O I：

10.1007/s00005-011-0112-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils are the first line of defense against bacterial and mycotic pathogens. In order to reach the pathogens, neutrophils need to transmigrate through the vascular endothelium and migrate to the site of infection. Defense strategies against pathogens include phagocytosis, production and release of oxygen radicals through the oxidative burst, and degranulation of antimicrobial and inflammatory molecules. Protein kinase C (PKC)-delta is required for full assembly of NADPH oxidase and activation of the respiratory burst. Neutrophils also express PKC-alpha and -beta, which may be involved in adhesion, degranulation and phagocytosis, but the evidence is not conclusive yet. This review focuses on the potential impact of protein kinase C isoforms on neutrophil adhesion and activation.

引用

页码：79 / 87

页数：9

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