Adoptive immunotherapy of cancer using ex vivo expanded human γδ T cells: A new approach

被引：46

作者：

Dokouhaki, Pouneh ^{[1
]}

Han, Mei ^{[1
]}

Joe, Betty ^{[1
]}

Li, Ming ^{[2
]}

Johnston, Michael R. ^{[1
]}

Tsao, Ming-Sound ^{[2
]}

Zhang, Li ^{[1
,2
,3
]}

机构：

[1] Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[3] Univ Toronto, Dept Immunol, Toronto, ON, Canada

来源：

CANCER LETTERS | 2010年 / 297卷 / 01期

关键词：

Adoptive T cell immunotherapy; Cancer immunotherapy; gamma delta T cells; TUMOR-INFILTRATING LYMPHOCYTES; EFFECTOR FUNCTIONS; ANTITUMOR-ACTIVITY; IN-VITRO; HUMAN NK; APOPTOSIS; RESISTANT; THERAPY; ANTIGEN; DIFFERENTIATION;

D O I：

10.1016/j.canlet.2010.05.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

gamma delta T cells can be an option for adoptive immunotherapy of cancer. The major obstacle to clinical application of gamma delta T cells is their low number and lack of a reliable method to expand them consistently and efficiently. We were able to expand gamma delta T cells with high purity in all donors regardless of their starting repertoire of gamma delta T cells. These ex vivo expanded gamma delta T cells are in early differentiation stage, can efficiently kill various tumors and inhibit growth of human lung cancer xeno-grafts. This new approach for ex vivo expansion of human gamma delta T cells will open new horizons for clinical use of these cells. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：126 / 136

页数：11

共 53 条

[1] Isopentenyl pyrophosphate-activated CD516+ γδ T lymphocytes display potent antitumor activity toward human squamous cell carcinoma [J].

Alexander, Alan A. Z. ;

Maniar, Amudhan ;

Cummings, Jean-Saville ;

Hebbeler, Andrew M. ;

Schulze, Dan H. ;

Gastman, Brian R. ;

Pauza, C. David ;

Strome, Scott E. ;

Chapoval, Andrei I. .

CLINICAL CANCER RESEARCH, 2008, 14 (13) :4232-4240

[2] Phase-I study of Innacell γδ™, an autologous cell-therapy product highly enriched in γ9δ2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma [J].

Bennouna, Jaafar ;

Bompas, Emmanuelle ;

Neidhardt, Eve Marie ;

Rolland, Frederic ;

Philip, Irene ;

Galea, Celine ;

Salot, Samuel ;

Saiagh, Soraya ;

Audrain, Marie ;

Rimbert, Marie ;

Micheaux, Sylvie Lafaye-de ;

Tiollier, Jerome ;

Negrier, Sylvie .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2008, 57 (11) :1599-1609

[3] Vγ9Vδ2 T cell-mediated recognition of human solid tumors.: Potential for immunotherapy of hepatocellular and colorectal carcinomas [J].

Bouet-Toussaint, Francoise ;

Cabillic, Florian ;

Toutirais, Olivier ;

Le Gallo, Matthieu ;

de la Pintiere, Cecile Thomas ;

Daniel, Pascale ;

Genetet, Noelle ;

Meunier, Bernard ;

Dupont-Bierre, Eric ;

Boudjema, Karim ;

Catros, Veronique .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2008, 57 (04) :531-539

[4] Professional antigen-presentation function by human γδ T cells [J].

Brandes, M ;

Willimann, K ;

Moser, B .

SCIENCE, 2005, 309 (5732) :264-268

[5] Cross-presenting human γδ T cells induce robust CD8+ αβ T cell responses [J].

Brandes, Marlene ;

Willimann, Katharina ;

Bioley, Gilles ;

Levy, Nicole ;

Eberl, Matthias ;

Luo, Ming ;

Tampe, Robert ;

Levy, Frederic ;

Romero, Pedro ;

Moser, Bernhard .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (07) :2307-2312

[6] Characterization and immunotherapeutic potential of γδ T-cells in patients with glioblastoma [J].

Bryant, Nichole L. ;

Suarez-Cuervo, Catalina ;

Gillespie, G. Yancey ;

Markert, James M. ;

Nabors, L. Burt ;

Meleth, Sreelatha ;

Lopez, Richard D. ;

Lamb, Lawrence S., Jr. .

NEURO-ONCOLOGY, 2009, 11 (04) :357-367

[7] Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vγ9Vδ2 naive, memory and effector T cell subsets [J].

Caccamo, N ;

Meraviglia, S ;

Ferlazzo, V ;

Angelini, D ;

Borsellino, G ;

Poccia, F ;

Battistini, L ;

Dieli, F ;

Salerno, A .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (06) :1764-1772

[8] Epigenetic and transcriptional programs lead to default IFN-γ production by γδ T cells [J].

Chen, Liang ;

He, Weifeng ;

Kim, Sean T. ;

Tao, Jian ;

Gao, Yunfei ;

Chi, Hongbo ;

Intlekofer, Andrew M. ;

Harvey, Bohdan ;

Reiner, Steven L. ;

Yin, Zhinan ;

Flavell, Richard A. ;

Craft, Joe .

JOURNAL OF IMMUNOLOGY, 2007, 178 (05) :2730-2736

[9]

CHOUDHARY A, 1995, J IMMUNOL, V154, P3932

[10] Vγ9Vδ2 T cell response to colon carcinoma cells [J].

Corvaisier, M ;

Moreau-Aubry, A ;

Diez, E ;

Bennouna, J ;

Mosnier, JF ;

Scotet, E ;

Bonneville, M ;

Jotereau, F .

JOURNAL OF IMMUNOLOGY, 2005, 175 (08) :5481-5488

← 1 2 3 4 5 6 →