Monosodium glutamate raises antral distension and plasma amino acid after a standard meal in humans

被引:36
作者
Boutry, Claire [1 ,2 ]
Matsumoto, Hideki [3 ]
Airinei, Gheorghe [4 ]
Benamouzig, Robert [1 ,2 ]
Tome, Daniel [1 ,2 ]
Blachier, Francois [1 ,2 ]
Bos, Cecile [1 ,2 ]
机构
[1] INRA, Res Ctr Human Nutr IdF, UMR914, Paris, France
[2] AgroParisTech, Res Ctr Human Nutr IdF, Nutr Physiol & Ingest Behav UMR914, Paris, France
[3] AJINOMOTO, Inst Life Sci, Amino Acid Basic & Appl Res Grp, Kawasaki, Kanagawa, Japan
[4] Avicenne Hosp, Serv Gastroenterol, Res Ctr Human Nutr IdF, Bobigny, France
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2011年 / 300卷 / 01期
关键词
monosodium glutamate; circulating amino acids; gastric antral area; postprandial metabolism; gastric emptying; REAL-TIME ULTRASONOGRAPHY; DIETARY GLUTAMATE; PROTEIN-INTAKE; INTESTINAL-ABSORPTION; INSULIN-SECRETION; METABOLISM LIMITS; GASTRIC-SECRETION; LEUCINE KINETICS; MILK PROTEIN; FED PIGLETS;
D O I
10.1152/ajpgi.00299.2010
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The consumption of monosodium glutamate (MSG) is advocated to elicit physiological and metabolic effects, yet these effects have been poorly investigated directly in humans and in particular in the postprandial phase. Thirteen healthy adults were supplemented for 6 days with a nutritional dose of MSG (2 g) or sodium chloride (NaCl) as control, following a crossover design. On the 7th day, they underwent a complete postprandial examination for the 6 h following the ingestion of the same liquid standard meal (700 kcal, 20% of energy as [N-15] protein, 50% as carbohydrate, and 30% as fat) supplemented with MSG or NaCl. Real-ultrasound measures of antral area indicated a significant increased distension for the 2 h following the meal supplemented with MSG vs. NaCl. This early postprandial phase was also associated with significantly increased levels of circulating leucine, isoleucine, valine, lysine, cysteine, alanine, tyrosine, and tryptophan after MSG compared with NaCl. No changes to the postprandial glucose, insulin, glucagon-like peptide (GLP)-1, and ghrelin were noted between MSG- and NaCl-supplemented meals. Subjective assessments of hunger and fullness were neither affected by MSG supplementation. Finally, the postprandial fate of dietary N was identical between dietary conditions. Our findings indicate that nutritional dose of MSG promoted greater postprandial elevations of several indispensable amino acids in plasma and induced gastric distension. Further work to elucidate the possible sparing effect of MSG on indispensable amino acid first-pass uptake in humans is warranted. This trial was registered at clinicaltrials.gov as NCT00862017.
引用
收藏
页码:G137 / G145
页数:9
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