Planar chiral mimetics. A new approach to ligand design for asymmetric catalysis

被引：21

作者：

Jones, G ^{[1
]}

Butler, DCD ^{[1
]}

Richards, CJ ^{[1
]}

机构：

[1] Cardiff Univ, Dept Chem, Cardiff CF10 3TB, S Glam, Wales

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 48期

基金：

英国工程与自然科学研究理事会;

关键词：

asymmetry; catalysts; metallocenes; oxazolines;

D O I：

10.1016/S0040-4039(00)01715-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(S)-Serine methyl ester is readily transformed into 4-(hydroxymethyl)oxazoline ligands containing either a 2-(eta (5)-cyclopentadienyl)(eta (4)-tetraphenylcyclobutadiene)cobalt or a 2-(1,2,3,4,5-pentaphenyl)-ferrocene substituent. The influence of the bulky metallocenes result in these ligands mimicking planar chirality, as demonstrated by their catalysis of the addition of diethylzinc to benzaldehyde resulting in (R)-1-phenylpropanol (75% e.e.). (C) 2000 Published by Elsevier Science Ltd.

引用

页码：9351 / 9354

页数：4

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