Clinical and epidemiological characteristics of the Philadelphia negative myeloproliferative neoplasms in Chile

被引：0

作者：

Valladares, Ximena ^{[1
]}

Benavente, Rafael ^{[1
]}

Rojas, Christine ^{[2
]}

Pena, Camila ^{[1
]}

Valenzuela, Rodrigo ^{[3
]}

Monardes, Virginia ^{[3
]}

Lopez, Hernan ^{[4
]}

Abarca, Marcelo ^{[5
]}

Leon, Pilar ^{[6
]}

Osorio, Rocio ^{[7
]}

Perez, Erika ^{[8
]}

Soto, Pablo ^{[9
]}

La Rocca, Gabriel ^{[10
]}

Cardemil, Daniela ^{[11
]}

Torres, Vivianne ^{[12
]}

Intriago, Marvila ^{[13
]}

Elena Cabrera, Maria ^{[1
,14
]}

Soledad Undurraga, Maria ^{[1
]}

机构：

[1] Hosp Salvador, Secc Hematol, Santiago, Chile

[2] Hosp Gustavo Fricke, Secc Hematol, Vina Del Mar, Chile

[3] Hosp Salvador, Lab Biol Mol, Santiago, Chile

[4] Hosp Barros Luco, Secc Hematol, Santiago, Chile

[5] Hosp Sotero del Rio, Secc Hematol, Santiago, Chile

[6] Hosp Carlos Van Buren, Secc Hematol, Valparaiso, Chile

[7] Hosp Juan Noe, Secc Hematol, Arica, Chile

[8] Hosp Reg Vallenar Huasco, Secc Hematol, Vallenar, Chile

[9] Hosp Puerto Montt, Secc Hematol, Puerto Montt, Chile

[10] Hosp Reg Coyhaique, Sect Hematol, Coyhaique, Chile

[11] Hosp Clin Magallanes, Secc Hematol, Punta Arenas, Chile

[12] Hosp Reg Valdivia, Secc Hematol, Valdivia, Chile

[13] Hosp La Serena, Secc Hematol, La Serena, Chile

[14] Univ Chile, Dept Med Interna Oriente, Santiago, Chile

来源：

REVISTA MEDICA DE CHILE | 2021年 / 149卷 / 11期

关键词：

Janus Kinase 2; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia; Essential; WORLD-HEALTH-ORGANIZATION; ESSENTIAL THROMBOCYTHEMIA; POLYCYTHEMIA-VERA; MYELOID NEOPLASMS; CLASSIFICATION; TRANSFORMATION; REVISION; LEUKEMIA;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are chronic hematological disorders characterized by the overproduction of one or more mature myeloid blood cell lineages. Classical Ph-MPN are polycythemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF). Aim: To assess the epidemiological, clinical and diagnostic characteristics of Ph-MPN in Chile. Material and Methods: Retrospective review of medical records of all patients referred as MPN from 2012 to 2017. Patients with (9;21) translocation were excluded. Results: Data of 462 cases with a median age of 69 years from 10 public hospitals was reviewed. ET was the most frequently Ph-MNP found. The incidence of Ph-MPN was 1.5 x 100.000 cases. The JAK2 V617F mutation study was performed in 96% of patients and only 30% had a bone marrow biopsy. Thrombotic events were observed in 29% of patients. Bleeding events were observed in 7%. Five-year overall survival was 87%. Conclusions: ET is the most frequent Ph-MPN. The mean incidence was lower than reported in the literature, in part because of a sub diagnosis.

引用

页码：1532 / 1538

页数：7

共 18 条

[1] Pathogenesis and Management of Thrombotic Disease in Myeloproliferative Neoplasms [J].