The repetitive activation of extracellular signal-regulated kinase is required for renal regeneration in rat

被引：6

作者：

Yano, T

Yano, Y

Yuasa, M

Horikawa, S

Ozasa, H

Okada, S

Otani, S

Hagiwara, K

机构：

[1] Natl Inst Hlth & Nutr, Div Appl Food Res, Shinjuku Ku, Tokyo 1628636, Japan

[2] Osaka City Univ, Sch Med, Dept Biochem 2, Osaka 545, Japan

[3] Tokyo Med & Dent Univ, Med Res Inst, Dept Pathol Biochem, Tokyo, Japan

[4] Minami Ikebukuro Clin, Tokyo, Japan

[5] Okayama Univ, Sch Med, Dept Pathol, Okayama 700, Japan

来源：

LIFE SCIENCES | 1998年 / 62卷 / 25期

关键词：

c-MET; EGF receptor; ERK; ornithine decarboxylase; renal regeneration levels;

D O I：

10.1016/S0024-3205(98)00215-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In this study, we investigated the activation of p42 extracellular signal-regulated kinase (ERK2) during renal regeneration after HgCl2-induced acute renal failure (ARF) in rat. ERK2 activation was observed at 5 and 29 hr after HgCl2, injection, respectively. The tyrosine phosphorylation of hepatocyte growth factor receptor (c-MET) occurred between 2.5 and 5 hr after the treatment. On the other hand, the phosphorylation of epidermal growth factor receptor (EGFR) was transiently observed at 29 hr after the injection. The peak of ornithine decarboxylase activity as a marker of G(1) phase was at 10 hr, and subsequently the labeling index of proliferating cell nuclear antigen as a marker of S phase increased at 53 hr. These results indicate that the repetitive activation of ERK2 related to the phosphorylation of c-MET and EGFR is required for the renal regeneration in HgCl2-induced ARF of rat.

引用

页码：2341 / 2347

页数：7

共 28 条

[21] IMMUNOCHEMICAL STUDY OF EPIDERMAL GROWTH-FACTOR IN RATS WITH MERCURIC CHLORIDE-INDUCED ACUTE-RENAL-FAILURE [J].