Humoral Response and SARS-CoV-2 Infection Risk following the Third and Fourth Doses of the BNT162b2 Vaccine in Dialysis Patients

被引：17

作者：

Einbinder, Yael ^{[1
,2
]}

Perl, Jeffrey ^{[3
,12
]}

Nacasch, Naomi ^{[1
,2
]}

Bnaya, Alon ^{[4
,5
]}

Shavit, Linda ^{[4
,5
]}

Erez, Daniel ^{[2
,6
]}

Shashar, Moshe ^{[2
,7
]}

Halperin, Tamar ^{[2
,8
]}

Grupper, Ayelet ^{[2
,9
]}

Benchetrit, Sydney ^{[1
,2
]}

Wand, Ori ^{[2
,10
,11
]}

Cohen-Hagai, Keren ^{[1
,2
]}

机构：

[1] Meir Med Ctr, Dept Nephrol & Hypertens, Kefar Sava, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[3] Univ Toronto, St Michaels Hosp, Div Nephrol, Toronto, ON, Canada

[4] Shaare Zedek Med Ctr, Inst Nephrol, Jerusalem, Israel

[5] Hebrew Univ Jerusalem, Jerusalem, Israel

[6] Meir Med Ctr, Dept Internal Med D, Kefar Sava, Israel

[7] Laniado Hosp, Dept Nephrol & Hypertens, Netanya, Israel

[8] Tel Aviv Sourasky Med Ctr, HIV Ctr, Lab HIV Diag, Tel Aviv, Israel

[9] Tel Aviv Sourasky Med Ctr Tel Aviv, Dept Nephrol & Hypertens, Tel Aviv, Israel

[10] Barzilai Govt Hosp, Pulm Div, Ashqelon, Israel

[11] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel

[12] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON, Canada

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 2022年 / 53卷 / 07期

关键词：

COVID-19; Hemodialysis; Vaccination; Humoral response;

D O I：

10.1159/000525309

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The optimal SARS-CoV-2 vaccination schedule in dialysis patients and the potential need for a fourth vaccine dose are debatable. We prospectively assessed the humoral responses to three and four doses of BNT162b2 among dialysis patients. The study included 106 dialysis patients; 60 (56.6%) and 46 (43.4%) received 3 and 4 vaccine doses, respectively. Anti-spike (anti-S) antibody titers significantly increased after the third vaccine dose, followed by a decline, yet still remained higher than all previous measurements. The fourth vaccine dose led to another profound rise in anti-S titers. The absolute increase following the fourth dose correlated with response to the third dose. Infection risk however was similar between patients vaccinated with three or four doses.

引用

页码：586 / 590

页数：5

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