FASTK family of genes linked to cancer

被引：6
作者：
Ramasubramanian, Abilasha [1 ]
Paramasivam, A. [2 ]
Ramani, Pratibha [1 ]
机构：
[1] Saveetha Univ, Saveetha Inst Med & Tech Sci, Dept Oral Pathol, Saveetha Dent Coll & Hosp, Poonamallee High Rd, Chennai 600077, Tamil Nadu, India
[2] Saveetha Univ, Saveetha Inst Med & Tech Sci, Dept Dent Res Cell Blue Lab, Saveetha Dent Coll & Hosp, Poonamallee High Rd, Chennai 600077, Tamil Nadu, India
来源：
BIOINFORMATION | 2022年 / 18卷 / 03期
关键词：
FAST; FASTK family; cancer; mitochondrial dysfunction; MITOCHONDRIAL RNA GRANULES; THERAPEUTIC TARGET; EXPRESSION; IDENTIFICATION; HALLMARKS; CELLS; TRANSCRIPTION; MUTATIONS; CARCINOMA; APOPTOSIS;
D O I：
10.6026/97320630018206
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Fas Activated Serine/Threonine Kinase (FASTK) family is a protein family encoded in the nuclear genome that spans the mitochondria and executes numerous functions, and consists of FASTK, the founding member along with 5 homologous proteins FASTKD1-5. Up regulation of FASTK family members have not only been implicated in tumour progression and invasion but also in increased resistance to chemotherapy proven by their knockdown leading to increased sensitivity to drugs. Thus, this review reports the implication of FASTK proteins in cancer and hence provides a scope to emphasise the role of these proteins in Oral Cancer.
引用
收藏
页码：206 / 213
页数：8
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