Standardized Passiflora incarnata L. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats

被引：9

作者：

Antunes Schunck, Rebeca Vargas ^{[1
,2
]}

Macedo, Isabel Cristina ^{[3
]}

Laste, Gabriela ^{[3
]}

de Souza, Andressa ^{[3
]}

Costa Valle, Marina Tuerlinckx ^{[1
,2
]}

Salomon, Janaina L. O. ^{[2
]}

Nunes, Ellen Almeida ^{[3
]}

Wildner Campos, Andreia Cristina ^{[4
]}

Baggio Gnoatto, Simone Cristina ^{[4
]}

Bergold, Ana Maria ^{[4
]}

Konrath, Eduardo L. ^{[4
]}

Dallegrave, Eliane ^{[5
]}

Arbo, Marcelo Dutra ^{[6
]}

Torres, Iraci L. S. ^{[1
,3
]}

Leal, Mirna Bainy ^{[1
,2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Programa Posgrad Ciencias Biol Neurociencias, Rua Sarmento Leite 500-107, BR-90050170 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Lab Farmacol & Toxicol Prod Nat, Dept Farmacol, Inst Ciencias Basicas Saude, Rua Sarmento Leite 500-202, BR-90050170 Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Lab Farmacol Dor & Neuromodulacao Invest Preclin, Dept Farmacol, Inst Ciencias Basicas Saude, Rua Sarmento Leite 500, BR-90050170 Porto Alegre, RS, Brazil

[4] Univ Fed Rio Grande do Sul, Fac Farm, Dept Prod Mat Prima, Av Ipiranga 2752, BR-90610000 Porto Alegre, RS, Brazil

[5] Univ Fed Ciencias Saude Porto Alegre, Univ Fed Ciencias, Dept Farmacociencias, Rua Sarmento Leite 245, BR-90050170 Porto Alegre, RS, Brazil

[6] Univ Fed Rio Grande do Sul, Dept Analises, Fac Farm, Lab Toxicol LATOX, Av Ipiranga 2752, BR-90050000 Porto Alegre, RS, Brazil

来源：

PHYTOTHERAPY RESEARCH | 2017年 / 31卷 / 08期

关键词：

Passiflora incarnata extract; pain; flavonoids; BDNF; IL-10; alcohol withdrawal; NEUROTROPHIC FACTOR; BENZOFLAVONE MOIETY; ETHANOL WITHDRAWAL; MEDICINAL-PLANTS; NEUROPATHIC PAIN; CHRONIC STRESS; BDNF; MODULATION; ACTIVATION; LINNEAUS;

D O I：

10.1002/ptr.5839

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Passiflora incarnata L. (Passifloraceae) has been traditionally used for treatment of anxiety, insomnia, drug addiction, mild infections, and pain. The aim of this study was to investigate the effect of a commercial extract of P. incarnata in the analgesia induced by alcohol withdrawal syndrome in rats. In addition, brain-derived neurotrophic factor and interleukin-10 levels were evaluated in prefrontal cortex, brainstem, and hippocampus. Male adult rats received by oral gavage: (1: water group) water for 19 days, 1 day interval and water (8 days); (2: P. incarnata group) water for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days); (3: alcohol withdrawal group) alcohol for 19 days, 1 day interval and water (8 days); and (4: P. incarnata in alcohol withdrawal) alcohol for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days). The tail-flick and hot plate tests were used as nociceptive response measures. Confirming previous study of our group, it was showed that alcohol-treated groups presented an increase in the nociceptive thresholds after alcohol withdrawal, which was reverted by P. incarnata, measured by the hot plate test. Besides, alcohol treatment increased brain-derived neurotrophic factor and interleukin-10 levels in prefrontal cortex, which was not reverted by P. incarnata. Considering these results, the P. incarnata treatment might be a potential therapy in the alcohol withdrawal syndrome. Copyright (C) 2017 John Wiley & Sons, Ltd.

引用

页码：1199 / 1208

页数：10

共 80 条

[1] Neuroprotective Effects of Vitexin, a Flavonoid, on Pentylenetetrazole-Induced Seizure in Rats [J].

Abbasi, Esmail ;

Nassiri-Asl, Marjan ;

Shafeei, Mahsa ;

Sheikhi, Mehdi .

CHEMICAL BIOLOGY & DRUG DESIGN, 2012, 80 (02) :274-278

[2] High-speed extraction and HPLC fingerprinting of medicinal plants -: I.: Application to Passiflora flavonoids [J].

Abourashed, EA ;

Vanderplank, JR ;

Khan, IA .

PHARMACEUTICAL BIOLOGY, 2002, 40 (02) :81-91

[3] Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam [J].

Akhondzadeh, S ;

Naghavi, HR ;

Vazirian, M ;

Shayeganpour, A ;

Rashidi, H ;

Khani, M .

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2001, 26 (05) :363-367

[4] Expression of cFos and brain-derived neurotrophic factor in cortex and hippocampus of ethanol-withdrawn male and female rats [J].

Alele, Paul E. ;

Devaud, Leslie L. .

JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS, 2013, 4 (04) :265-274

[5] Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms [J].

Aman, Urooj ;

Subhan, Fazal ;

Shahid, Muhammad ;

Akbar, Shehla ;

Ahmad, Nisar ;

Ali, Gowhar ;

Fawad, Khwaja ;

Sewell, Robert D. E. .

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2016, 16

[6]

[Anonymous], MARACUJA HERBAL SECR

[7]

[Anonymous], FITOTERAPICOS

[8] Protracted alcohol abstinence induces analgesia in rats: Possible relationships with BDNF and interleukin-10 [J].

Antunes Schunck, Rebeca Vargas ;

Torres, Iraci L. S. ;

Laste, Gabriela ;

de Souza, Andressa ;

Macedo, Isabel Cristina ;

Costa Valle, Marina Tuerlincla ;

Salomon, Janaina L. O. ;

Moreira, Sonia ;

Kuo, Jonnsin ;

Arbo, Marcelo Dutra ;

Dallegrave, Eliane ;

Leal, Mima Bainy .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2015, 135 :64-69

[9] Modulation of the γ-Aminobutyric Acid (GABA) System by Passiflora incarnata L. [J].

Appel, Kurt ;

Rose, Thorsten ;

Fiebich, Bernd ;

Kammler, Thomas ;

Hoffmann, Christine ;

Weiss, Gabriele .

PHYTOTHERAPY RESEARCH, 2011, 25 (06) :838-843

[10] Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies [J].

Blednov, Yuri A. ;

Ponomarev, Igor ;

Geil, Chelsea ;

Bergeson, Susan ;

Koob, George F. ;

Harris, R. Adron .

ADDICTION BIOLOGY, 2012, 17 (01) :108-120

← 1 2 3 4 5 6 7 8 →