White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed

被引：61

作者：

Freeze, Whitney M. ^{[1
,2
]}

Jacobs, Heidi I. L. ^{[1
,3
]}

de Jong, Joost J. ^{[2
]}

Verheggen, Inge C. M. ^{[1
]}

Gronenschild, Ed H. B. M. ^{[1
]}

Palm, Walter M. ^{[2
]}

Hoff, Erik I. ^{[4
]}

Wardlaw, Joanna M. ^{[5
,6
]}

Jansen, Jacobus F. A. ^{[2
]}

Verhey, Frans R. ^{[1
]}

Backes, Walter H. ^{[2
]}

机构：

[1] Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[2] Maastricht Univ, Med Ctr, Sch Mental Hlth & Neurosci, Dept Radiol & Nucl Med, POB 5800, NL-6202 AZ Maastricht, Netherlands

[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA 02115 USA

[4] Zuyderland Med Ctr Heerlen, Dept Neurol, Heerlen, Netherlands

[5] Univ Edinburgh, Ctr Clin Brain Sci, Brain Res Imaging Ctr, Edinburgh, Midlothian, Scotland

[6] Univ Edinburgh, UK Dementia Res Inst, Edinburgh, Midlothian, Scotland

来源：

NEUROBIOLOGY OF AGING | 2020年 / 85卷

基金：

英国医学研究理事会;

关键词：

Blood-brain barrier; Cognition; Hippocampus; Small vessel disease; White matter hyperintensities; SMALL-VESSEL DISEASE; PARTICIPANTS AGED 24-81; ALZHEIMERS-DISEASE; NORMATIVE DATA; SIGNAL ABNORMALITIES; NATIONAL INSTITUTE; DEMENTIA; EDUCATION; VOLUME; MRI;

D O I：

10.1016/j.neurobiolaging.2019.09.017

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Blood-brain barrier (BBB) leakage is considered an important underlying process in both cerebral small vessel disease (cSVD) and Alzheimer's disease (AD). The objective of this study was to examine associations between BBB leakage, cSVD, neurodegeneration, and cognitive performance across the spectrum from normal cognition to dementia. Leakage was measured with dynamic contrast-enhanced magnetic resonance imaging in 80 older participants (normal cognition, n = 32; mild cognitive impairment, n 34; clinical AD-type dementia, n = 14). Associations between leakage and white matter hyperintensity (WMH) volume, hippocampal volume, and cognition (information processing speed and memory performance) were examined with multivariable linear regression and mediation analyses. Leakage within the gray and white matter was positively associated with WMH volume (gray matter, p = 0.03; white matter, p = 0.01). A negative association was found between white matter BBB leakage and information processing speed performance, which was mediated by WMH volume. Leakage was not associated with hippocampal volume. WMH pathology is suggested to form a link between leakage and decline of information processing speed in older individuals with and without cognitive impairment. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：113 / 122

页数：10

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