Ycf1p attenuates basal level oxidative stress response in Saccharomyces cerevisiae

被引：10
|
作者：
Paumi, Christian M. [1 ]
Pickin, Kerry A. [2 ]
Jarrar, Roaa [1 ]
Herren, Catherine K. [2 ]
Cowley, Stuart T. [2 ]
机构：
[1] Univ Kentucky, Dept Toxicol, Lexington, KY 40536 USA
[2] Ctr Coll Danville, Dept Chem, Danville, KY 40422 USA
来源：
FEBS LETTERS | 2012年 / 586卷 / 06期
关键词：
Ycf1p; Salt stress; Super oxide dismutase; Catalase; Glutathione; Glutathione peroxidase; CADMIUM-GLUTATHIONE COMPLEX; ABC TRANSPORTER YCF1P; SUPEROXIDE-DISMUTASE; PROTEINS; BIOLOGY; CATALASE; REVEALS; PATHWAY;
D O I：
10.1016/j.febslet.2012.02.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ycf1p function is regulated by casein kinase 2 alpha, Cka1p, via phosphorylation of Ser251. Cka1p-mediated phosphorylation of Ycf1p is attenuated in response to high salt stress. Previous results from our lab suggest a role for Ycf1p in cellular resistance to salt stress. Here, we show that Ycf1p plays an important role in cellular resistance to salt stress by maintaining the cellular redox balance via glutathione recycling. Our results suggest that during acute salt stress increased Sod1p, Sod2p and Ctt1p activity is the main compensatory for the loss in Ycf1p function that results from reduced Ycf1p-dependent recycling of cellular GSH levels. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：847 / 853
页数：7
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