New pharmacological approaches to atrial fibrillation

被引：21

作者：

Milnes, James T. ^{[1
]}

Madge, David J. ^{[1
]}

Ford, John W. ^{[1
]}

机构：

[1] Xention Ltd, Cambridge CB22 3EG, England

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 13-14期

关键词：

DELAYED RECTIFIER CURRENT; POTASSIUM CURRENT; ANTIARRHYTHMIC-DRUG; OUTWARD CURRENT; IKACH BLOCKER; I-KUR; CHANNEL; HYPERPOLARIZATION; RANOLAZINE; AMIODARONE;

D O I：

10.1016/j.drudis.2012.02.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atrial fibrillation (AF) is the most common cardiac arrhythmia facing physicians, afflicting 13% of men and 11% of women over 85 years of age. Epidemiological studies estimate that there are >= 11 million AF sufferers in the seven major economies and that its prevalence will increase two- to threefold over the next 50 years. Current strategies for treating AF involve either sinus rhythm (SR) maintenance or heart rate control, combined with anticoagulation therapy. Although SR control is the preferred and most effective treatment of AF, none of the SR control drugs currently available are able to maintain rhythm without significant side effects. In this article we discuss some of the recent advancements in developing new antiarrhythmic drugs for AF.

引用

收藏

页码：654 / 659

页数：6

相关论文

共 41 条

[31]

Shiroshita-Takeshita A., 2006, HEART RHYTHM, V3, pP3

[32] A multiple ion channel blocker, NIP-142, for the treatment of atrial fibrillation [J].

Tanaka, Hikaru ;

Hashimoto, Norio .

CARDIOVASCULAR DRUG REVIEWS, 2007, 25 (04) :342-356

[33] Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation [J].

Voigt, Niels ;

Friedrich, Adina ;

Bock, Manja ;

Wettwer, Erich ;

Christ, Torsten ;

Knaut, Michael ;

Strasser, Ruth H. ;

Ravens, Ursula ;

Dobrev, Dobromir .

CARDIOVASCULAR RESEARCH, 2007, 74 (03) :426-437

[34] Left-to-Right Atrial Inward Rectifier Potassium Current Gradients in Patients With Paroxysmal Versus Chronic Atrial Fibrillation [J].

Voigt, Niels ;

Trausch, Anne ;

Knaut, Michael ;

Matschke, Klaus ;

Varro, Andras ;

Van Wagoner, David R. ;

Nattel, Stanley ;

Ravens, Ursula ;

Dobrev, Dobromir .

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2010, 3 (05) :472-U78

[35] SUSTAINED DEPOLARIZATION-INDUCED OUTWARD CURRENT IN HUMAN ATRIAL MYOCYTES - EVIDENCE FOR A NOVEL DELAYED RECTIFIER K+ CURRENT SIMILAR TO KV1.5 CLONED CHANNEL CURRENTS [J].

WANG, ZG ;

FERMINI, B ;

NATTEL, S .

CIRCULATION RESEARCH, 1993, 73 (06) :1061-1076

[36] Role of IKur in controlling action potential shape and contractility in the human atrium -: Influence of chronic atrial fibrillation [J].

Wettwer, E ;

Hála, O ;

Christ, T ;

Heubach, JF ;

Dobrev, D ;

Knaut, M ;

Varró, A ;

Ravens, U .

CIRCULATION, 2004, 110 (16) :2299-2306

[37] Abnormal heart rate regulation in GIRK4 knockout mice [J].

Wickman, K ;

Nemec, J ;

Gendler, SJ ;

Clapham, DE .

NEURON, 1998, 20 (01) :103-114

[38]

Xing DZ, 2009, CIRCULATION, V120, pS654

[39] Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium [J].

Yang, Dongli ;

Zhang, Xiaoming ;

Hughes, Bret A. .

EXPERIMENTAL EYE RESEARCH, 2008, 87 (03) :176-183

[40] Somatostatin induces hyperpolarization in pancreatic islet a cells by activating a G protein-gated K+ channel [J].

Yoshimoto, Y ;

Fukuyama, Y ;

Horio, Y ;

Inanobe, A ;

Gotoh, M ;

Kurachi, Y .

FEBS LETTERS, 1999, 444 (2-3) :265-269

← 1 2 3 4 5 →