New pharmacological approaches to atrial fibrillation

被引：21

作者：

Milnes, James T. ^{[1
]}

Madge, David J. ^{[1
]}

Ford, John W. ^{[1
]}

机构：

[1] Xention Ltd, Cambridge CB22 3EG, England

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 13-14期

关键词：

DELAYED RECTIFIER CURRENT; POTASSIUM CURRENT; ANTIARRHYTHMIC-DRUG; OUTWARD CURRENT; IKACH BLOCKER; I-KUR; CHANNEL; HYPERPOLARIZATION; RANOLAZINE; AMIODARONE;

D O I：

10.1016/j.drudis.2012.02.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atrial fibrillation (AF) is the most common cardiac arrhythmia facing physicians, afflicting 13% of men and 11% of women over 85 years of age. Epidemiological studies estimate that there are >= 11 million AF sufferers in the seven major economies and that its prevalence will increase two- to threefold over the next 50 years. Current strategies for treating AF involve either sinus rhythm (SR) maintenance or heart rate control, combined with anticoagulation therapy. Although SR control is the preferred and most effective treatment of AF, none of the SR control drugs currently available are able to maintain rhythm without significant side effects. In this article we discuss some of the recent advancements in developing new antiarrhythmic drugs for AF.

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页码：654 / 659

页数：6

相关论文

共 41 条

[1] Differences between outward currents of human atrial, and subepicardial ventricular myocytes [J].

Amos, GJ ;

Wettwer, E ;

Metzger, F ;

Li, Q ;

Himmel, HM ;

Ravens, U .

JOURNAL OF PHYSIOLOGY-LONDON, 1996, 491 (01) :31-50

[2]

Beatch GN, 2003, CIRCULATION, V108, P85

[3] Atrial Selective Effects of Intravenously Administered Vernakalant in Conscious Beagle Dogs [J].

Bechard, Jeff ;

Pourrier, Marc .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2011, 58 (01) :49-55

[4] Selective Kv1.5 Blockers: Development of (R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a Potential Treatment for Atrial Arrhythmia [J].

Blass, Benjamin E. ;

Fensome, Andrew ;

Trybulski, Eugene ;

Magolda, Ronald ;

Gardell, Stephen J. ;

Liu, Kun ;

Samuel, Manoj ;

Feingold, Irene ;

Huselton, Christine ;

Jackson, Chris M. ;

Djandjighian, Laurent ;

Ho, Douglas ;

Hennan, James ;

Janusz, John M. .

JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (21) :6531-6534

[5] Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation - Differences in sodium channel inactivation between atria and ventricles and the role of ranolazine [J].

Burashnikov, Alexander ;

Di Diego, Jose M. ;

Zygmunt, Andrew C. ;

Belardinelli, Luiz ;

Antzelevitch, Charles .

CIRCULATION, 2007, 116 (13) :1449-1457

[6] Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation [J].

Burashnikov, Alexander ;

Di Diego, Jose M. ;

Sicouri, Serge ;

Ferreiro, Marceta ;

Carlsson, Leif ;

Antzeevitch, Charles .

HEART RHYTHM, 2008, 5 (12) :1735-1742

[7] In Humans, Chronic Atrial Fibrillation Decreases the Transient Outward Current and Ultrarapid Component of the Delayed Rectifier Current Differentially on Each Atria and Increases the Slow Component of the Delayed Rectifier Current in Both [J].

Caballero, Ricardo ;

Gonzalez de la Fuente, Marta ;

Gomez, Ricardo ;

Amoros, Irene ;

Dolz-Gaiton, Pablo ;

Osuna, Lourdes ;

Almendral, Jesus ;

Atienza, Felipe ;

Fernandez-Aviles, Francisco ;

Pita, Ana ;

Rodriguez-Roda, Jorge ;

Pinto, Angel ;

Tamargo, Juan ;

Delpon, Eva .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (21) :2346-2354

[8] A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins [J].

Chan, KW ;

Langan, MN ;

Sui, JL ;

Kozak, JA ;

Pabon, A ;

Ladias, JAA ;

Logothetis, DE .

JOURNAL OF GENERAL PHYSIOLOGY, 1996, 107 (03) :381-397

[9] K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension [J].

Choi, Murim ;

Scholl, Ute I. ;

Yue, Peng ;

Bjoerklund, Peyman ;

Zhao, Bixiao ;

Nelson-Williams, Carol ;

Ji, Weizhen ;

Cho, Yoonsang ;

Patel, Aniruddh ;

Men, Clara J. ;

Lolis, Elias ;

Wisgerhof, Max V. ;

Geller, David S. ;

Mane, Shrikant ;

Hellman, Per ;

Westin, Gunnar ;

Akerstrom, Goran ;

Wang, Wenhui ;

Carling, Tobias ;

Lifton, Richard P. .

SCIENCE, 2011, 331 (6018) :768-772

[10] Autonomic influences in atrial tachyarrhythmias [J].

Coumel, P .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 1996, 7 (10) :999-1007

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