Promoting metastasis: neutrophils and T cells join forces

被引:21
作者
Fridlender, Zvi G. [1 ]
Albelda, Steven M. [2 ]
Granot, Zvi [3 ]
机构
[1] Hadassah Hebrew Univ, Med Ctr, Inst Pulm Med, IL-91120 Jerusalem, Israel
[2] Univ Penn, Thorac Oncol Res Lab, Philadelphia, PA 19104 USA
[3] Hebrew Univ Jerusalem, Sch Med, Inst Med Res Israel Canada, Dept Dev Biol & Canc Res, IL-91120 Jerusalem, Israel
关键词
CANCER; LUNG; TAN;
D O I
10.1038/cr.2015.62
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The role neutrophils play in cancer is a matter of debate as both pro-and anti-tumor functions have been documented. In a recent publication in Nature, Coffelt et al. identify a new mechanism where neutrophils and T cells cooperate to generate metastasis-supporting immune suppression.
引用
收藏
页码:765 / 766
页数:2
相关论文
共 10 条
[1]   IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis [J].
Coffelt, Seth B. ;
Kersten, Kelly ;
Doornebal, Chris W. ;
Weiden, Jorieke ;
Vrijland, Kim ;
Hau, Cheei-Sing ;
Verstegen, Niels J. M. ;
Ciampricotti, Metamia ;
Hawinkels, Lukas J. A. C. ;
Jonkers, Jos ;
de Visser, Karin E. .
NATURE, 2015, 522 (7556) :345-+
[2]   Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer [J].
Eruslanov, Evgeniy B. ;
Bhojnagarwala, Pratik S. ;
Quatromoni, Jon G. ;
Stephen, Tom Li ;
Ranganathan, Anjana ;
Deshpande, Charuhas ;
Akimova, Tatiana ;
Vachani, Anil ;
Litzky, Leslie ;
Hancock, Wayne W. ;
Conejo-Garcia, Jose R. ;
Feldman, Michael ;
Albeida, Steven M. ;
Singhal, Sunil .
JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (12) :5466-5480
[3]   Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: "N1" versus "N2" TAN [J].
Fridlender, Zvi G. ;
Sun, Jing ;
Kim, Samuel ;
Kapoor, Veena ;
Cheng, Guanjun ;
Ling, Leona ;
Worthen, G. Scott ;
Albelda, Steven M. .
CANCER CELL, 2009, 16 (03) :183-194
[4]   Tumor associated macrophages and neutrophils in cancer [J].
Galdiero, Maria Rosaria ;
Bonavita, Eduardo ;
Barajon, Isabella ;
Garlanda, Cecilia ;
Mantovani, Alberto ;
Jaillon, Sebastien .
IMMUNOBIOLOGY, 2013, 218 (11) :1402-1410
[5]   Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung [J].
Granot, Zvi ;
Henke, Erik ;
Comen, Elizabeth A. ;
King, Tari A. ;
Norton, Larry ;
Benezra, Robert .
CANCER CELL, 2011, 20 (03) :300-314
[6]   Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression [J].
Lopez-Lago, M. A. ;
Posner, S. ;
Thodima, V. J. ;
Molina, A. M. ;
Motzer, R. J. ;
Chaganti, R. S. K. .
ONCOGENE, 2013, 32 (14) :1752-1760
[7]   Neutrophils recruit regulatory T-cells into tumors via secretion of CCL17-A new mechanism of impaired antitumor immunity [J].
Mishalian, Inbal ;
Bayuh, Rachel ;
Eruslanov, Evgeniy ;
Michaeli, Janna ;
Levy, Liran ;
Zolotarov, Lida ;
Singhal, Sunil ;
Albelda, Steven M. ;
Granot, Zvi ;
Fridlender, Zvi G. .
INTERNATIONAL JOURNAL OF CANCER, 2014, 135 (05) :1178-1186
[8]   Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression [J].
Mishalian, Inbal ;
Bayuh, Rachel ;
Levy, Liran ;
Zolotarov, Lida ;
Michaeli, Janna ;
Fridlender, Zvi Gregorio .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2013, 62 (11) :1745-1756
[9]   Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer [J].
Sagiv, Jitka Y. ;
Michaeli, Janna ;
Assi, Simaan ;
Mishalian, Inbal ;
Kisos, Hen ;
Levy, Liran ;
Damti, Pazzit ;
Lumbroso, Delphine ;
Polyansky, Lola ;
Sionov, Ronit V. ;
Ariel, Amiram ;
Hovav, Avi-Hai ;
Henke, Erik ;
Fridlender, Zvi G. ;
Granot, Zvi .
CELL REPORTS, 2015, 10 (04) :562-573
[10]   The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment [J].
Sionov, Ronit Vogt ;
Fridlender, Zvi G. ;
Granot, Zvi .
CANCER MICROENVIRONMENT, 2015, 8 (03) :125-158