PAYCS Alleviates Scopolamine-Induced Memory Deficits in Mice by Reducing Oxidative and Inflammatory Stress and Modulation of Gut Microbiota-Fecal Metabolites-Brain Neurotransmitter Axis

被引：19

作者：

Zhao, Tiantian ^{[1
,2
]}

Zhong, Saiyi ^{[2
]}

Xu, Jucai ^{[3
]}

Jiao, Wenjuan ^{[1
]}

Liu, Weifeng ^{[1
]}

Huang, Lihua ^{[4
]}

Zhang, Yehui ^{[1
]}

Zhang, Yousheng ^{[1
]}

机构：

[1] Guangdong Acad Agr Sci, Sericulture & Agri Food Res Inst, Key Lab Funct Foods, Minist Agr & Rural Affairs,Guangdong Key Lab Agr, Guangzhou 510610, Peoples R China

[2] Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China

[3] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China

[4] Guangzhou City Polytech, Dept Food, Guangzhou 510405, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2022年 / 70卷 / 09期

关键词：

peptides; scopolamine; gut microbiota; fecal metabolites; brain neurotransmitters; AMYLOID-BETA; BIOACTIVE PEPTIDES; NEUROINFLAMMATION; ANTIOXIDANT; DISORDERS; STRATEGY; HEALTH; MODEL;

D O I：

10.1021/acs.jafc.1c06726

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The bioactive peptide PAYCS (Pro-Ala-Tyr-Cys-Ser) identified from anchovy hydrolysates has been reported to be positive in memory alleviation. The gut microbiota-brain axis plays a vital role in brain functions, which could be affected by nutritional supplementation. Herein, we found that PAYCS at different concentrations (PAYCS-L and PAYCS-H) showed various improving effects in behavioral tests and alleviation effects on oxidative as well as inflammatory stress in the scopolamine-induced AD mouse model. The 16S rRNA results illustrated that PAYCS-L altered the ratio of Bacteroidetes/Firmicutes and PAYCS treatment elevated the relative abundance of Cacteroidaceae and Prevotellaceae. Notably, administration of PAYCS significantly upregulated memory-related metabolites and neurotransmitters. Overall, PAYCS-L reversed memory deficits of amnesiac mice partially via the modulation of gut microbiota-metabolites-brain neurotransmitter axis. For PAYCS-H, functions might be involved in the reversal of oxidative and inflammatory impairments in the liver and serum, which was also associated with the changed intestinal microbiota and fecal metabolites.

引用

页码：2864 / 2875

页数：12

共 53 条

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