Effects of the Dental Caries Preventive Procedure on the White Spot Lesions during Orthodontic Treatment-An Open Label Randomized Controlled Trial

被引：6
作者：
Shimpo, Yudai [1 ]
Nomura, Yoshiaki [2 ,3 ]
Sekiya, Toshiko [1 ]
Arai, Chihiro [1 ]
Okada, Ayako [4 ]
Sogabe, Kaoru [2 ]
Hanada, Nobuhiro [3 ]
Tomonari, Hiroshi [1 ]
机构：
[1] Tsurumi Univ, Sch Dent Med, Dept Orthodont, Yokohama, Kanagawa 2308501, Japan
[2] Tsurumi Univ, Sch Dent Med, Dept Translat Res, Yokohama, Kanagawa 2308501, Japan
[3] Univ Shanghai Sci & Technol, Int Photocatalyst Res Inst, 516 Jungong Rd, Shanghai 200093, Peoples R China
[4] Tsurumi Univ, Sch Dent Med, Dept Operat Dent, Yokohama, Kanagawa 2308501, Japan
来源：
JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 03期
关键词：
tooth surface disinfection; quantitative light-induced fluorescence; mixed effect model; fixed orthodontic treatment; oral microbiome; LIGHT-INDUCED FLUORESCENCE; ENAMEL DEMINERALIZATION; INTERNATIONAL CARIES; FLUORIDE VARNISH; MOUTH RINSE; IN-VITRO; APPLIANCES; BRACKETS; REMINERALIZATION; QUANTIFICATION;
D O I：
10.3390/jcm11030854
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
(1) Background: The aim of this study was to assess the preventive effect of tooth surface disinfection treatment, in addition to fluoride application, during fixed orthodontic treatment. (2) Methods: An open label randomized control trial for the evaluation of the dental caries preventive procedure was performed for the patients with high caries risk who had been visited at Department of Orthodontics, Tsurumi University Dental Hospital for orthodontics treatment. The follow-up period was six months. White spot lesions (WSLs) were evaluated by quantitative light-induced fluorescence (QLF). Cariogenic bacteria were monitored and evaluated by bacterial culture. In addition, the oral microbiome was evaluated by a next-generation sequence (NGS). (3) Results: By the mixed effect modeling, tooth surface disinfection treatment significantly reduced cariogenic bacteria and all parameters obtained by QLF. (4) Conclusions: Tooth surface disinfection treatment, in addition to PMTC and fluoride application, were effective for dental caries prevention and keeping a healthy microbiome during orthodontic treatment.
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页数：16
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