DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases

被引：15

作者：

Liu, Gang ^{[1
]}

Bin, Peng ^{[1
,2
]}

Wang, Tianwei ^{[2
,3
]}

Ren, Wenkai K ^{[1
,2
]}

Zhong, Jin ^{[3
]}

Liang, Jun ^{[4
]}

Hu, Chien-An Andy ^{[5
,6
]}

Zeng, Zhaoying ^{[1
]}

Yin, Yulong ^{[1
,6
,7
]}

机构：

[1] Chinese Acad Sci, Inst Subtrop Agr, Hunan Prov Engn Res Ctr Hlth Livestock,Hunan Coin, Key Lab Agroecol Proc Subtrop Reg,Natl Engn Lab P, Changsha 410125, Hunan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100101, Peoples R China

[4] Tianjin Univ Sci & Technol, Coll Packaging & Printing Engn, Tianjin 300222, Peoples R China

[5] Univ New Mexico, Sch Med, Dept Biochem & Mol Biol, MSC08 4670,Fitz 258, Albuquerque, NM 87131 USA

[6] Hunan Normal Univ, Sch Life Sci, Anim Nutr & Human Hlth Lab, Changsha 410081, Hunan, Peoples R China

[7] South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2017年 / 2017卷

基金：

中国国家自然科学基金;

关键词：

MODIFICATIONS BASIC MECHANISMS; FOLIC-ACID SUPPLEMENTATION; MODERATE FOLATE-DEPLETION; PLASMA HOMOCYSTEINE; S-ADENOSYLHOMOCYSTEINE; UPDATED METAANALYSIS; RISK-FACTOR; HYPOMETHYLATION; CYSTEINE; GENE;

D O I：

10.1155/2017/1670815

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Patients suffering from cardiovascular diseases (CVDs) experience a low quality of life and increase pressure on healthcare systems both nationally and globally. DNA methylation, which refers to the pathway by which DNA methyltransferase facilitates the addition of a methyl group to DNA, is of critical importance in this respect primarily because the epigenetic modification is implicated in a range of serious conditions including atherosclerosis, CVDs, and cancer. Research findings indicate that the number of epigenetic alterations can be elicited (both in utero and in adults) through the administration of certain nutritional supplements, including folic acid and methionine; this is partly attributable to the effect employed by methyl-containing nutrients in DNA methylation. Thus, for the purpose of illuminating viable therapeutic measures and preventive strategies for CVDs, research should continue to explore the intricate associations that exist between epigenetic regulation and CVD pathogenesis. This review centers on an exposition of the mechanism by which DNA methylation takes place, the impact it has on a range of conditions, and the potential clinical value of nutrition, driven mainly by the observation that nutritional supplements such as folic acid can affect DNA methylation.

引用

页数：7