Silica gel-mediated hydrohalogenation of unactivated alkenes using hydrohalogenic acids under organic solvent-free conditions

被引：17
|
作者：
Tanemura, Kiyoshi [1 ]
机构：
[1] Nippon Dent Univ, Chem Lab, Sch Life Dent Niigata, Hamaura Cho, Niigata 9518580, Japan
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 49期
关键词：
Silica gel; Alkenes; Solvent-free conditions; Addition; Hydrochloric acid; Hydrogen chloride; MICROWAVE-ASSISTED SYNTHESIS; REGIOSELECTIVE HYDROCHLORINATION; HYDROGEN-CHLORIDE; SOLID MEDIA; ALUMINA; OLEFINS; SURFACE; HYDROBROMINATION; REAGENTS; KETONES;
D O I：
10.1016/j.tetlet.2018.10.043
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Silica gel-mediated hydrochlorination of unactivated alkenes using 35% hydrochloric acid under organic solvent-free conditions proceeded to give the corresponding chlorides in good yields. Hydrobromination or hydriodination using 47% hydrobromic acid or 55% hydriodic acid afforded the corresponding halides, respectively. Silica gel could be recycled five times without any significant loss of activities. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4293 / 4298
页数：6
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