Self-assembled nano-micelles of lactoferrin peptides: Structure, physicochemical properties, and application for encapsulating and delivering curcumin

被引：43

作者：

Wang, Yiyang ^{[1
]}

Jiang, Wen ^{[1
]}

Jiang, Yuchu ^{[1
]}

McClements, David Julian ^{[2
]}

Liu, Fuguo ^{[1
]}

Liu, Xuebo ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China

[2] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA

来源：

FOOD CHEMISTRY | 2022年 / 387卷

基金：

中国国家自然科学基金;

关键词：

Nano-micelle; Self-assembly; Protein hydrolysate; Ultrasound; Curcumin; NUTRACEUTICAL BIOAVAILABILITY; EXCIPIENT EMULSIONS; SERUM-ALBUMIN; BIOACCESSIBILITY; NANOPARTICLES; STABILITY; PROTEIN; DRUG; FLUORESCENCE; PROTECTION;

D O I：

10.1016/j.foodchem.2022.132790

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Food-derived protein hydrolysate exhibits good bioactivity, compatibility, and low toxicity, etc. However, the information on protein hydrolysate-based micelles and their application as carriers for hydrophobic bioactive compounds is limited. In this study, an enzymatic partially hydrolyzed lactoferrin hydrolysate nano-micelle with the size within 50 nm was constructed, and its formation mechanism and delivery characteristics for curcumin (Cur) were studied. The results demonstrated that Cur was loaded into the micelles through hydrophobic interaction, and the encapsulation rate of Cur by nano-micelles was (93.44 +/- 0.01)%. In addition, the nanomicelle system demonstrated excellent thermal stability, dilution stability, and storage stability. The in vitro simulated digestion proved that self-assembled nano-micelles could improve the transformation rate and bioaccessibility of Cur. This study revealed that lactoferrin hydrolysate self-assembled nano-micelle is a promising delivery system for hydrophobic bioactive compounds.

引用

页数：10

共 39 条

[1] Whey protein peptides as components of nanoemulsions: A review of emulsifying and biological functionalities [J].

Adjonu, Randy ;

Doran, Gregory ;

Torley, Peter ;

Agboola, Samson .

JOURNAL OF FOOD ENGINEERING, 2014, 122 :15-27

[2] Neuroprotective effect of curcumin-loaded lactoferrin nano particles against rotenone induced neurotoxicity [J].

Bollimpelli, V. Satish ;

Kumar, Prashant ;

Kumari, Sonali ;

Kondapi, Anand K. .

NEUROCHEMISTRY INTERNATIONAL, 2016, 95 :37-45

[3] Interactions between 1-benzoyl-4-p-chlorophenyl thiosemicarbazide and serum albumin:: investigation by fluorescence spectroscopy [J].

Cui, FL ;

Fan, J ;

Li, JP ;

Hu, ZD .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (01) :151-157

[4] Zein-based colloidal particles for encapsulation epigallocatechin gallate and delivery of epigallocatechin gallate [J].

Donsi, Francesco ;

Voudouris, Panayiotis ;

Veen, Sandra J. ;

Velikov, Krassimir P. .

FOOD HYDROCOLLOIDS, 2017, 63 :508-517

[5] Nano-carrier systems: Strategies to overcome the mucus gel barrier [J].

Duennhaupt, S. ;

Kammona, O. ;

Waldner, C. ;

Kiparissides, C. ;

Bernkop-Schnuerch, A. .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2015, 96 :447-453

[6] Albumin-based nanoparticles as potential controlled release drug delivery systems [J].

Elzoghby, Ahmed O. ;

Samy, Wael M. ;

Elgindy, Nazik A. .

JOURNAL OF CONTROLLED RELEASE, 2012, 157 (02) :168-182

[7] Stability of trianionic curcumin enhanced by gemini alkyl O-Glucosides and alkyl trimethyl ammonium halides mixed micelles [J].

Feng, Jin ;

Wu, Shanshan ;

Wang, Hua ;

Liu, Songbai .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2016, 504 :190-200

[8] Characterization and functional properties of rice bran proteins modified by commercial exoproteases and endoproteases [J].

Hamada, JS .

JOURNAL OF FOOD SCIENCE, 2000, 65 (02) :305-310

[9] Enhancement of curcumin water dispersibility and antioxidant activity using core-shell protein-polysaccharide nanoparticles [J].

Huang, Xiaoxia ;

Huang, Xulin ;

Gong, Yushi ;

Xiao, Hang ;

McClements, David Julian ;

Hu, Kun .

FOOD RESEARCH INTERNATIONAL, 2016, 87 :1-9

[10] Self-assembly of hydrophobin and its co-assembly with hydrophobic nutraceuticals in aqueous solutions: Towards application as delivery systems [J].

Israeli-Lev, Gal ;

Livney, Yoav D. .

FOOD HYDROCOLLOIDS, 2014, 35 :28-35

← 1 2 3 4 →