Deficiency of heme-regulated eIF2α kinase decreases hepcidin expression and splenic iron in HFE-/- mice

被引：19

作者：

Liu, Sijin ^{[1
]}

Suragani, Rajasekhar N. V. S. ^{[1
]}

Han, Anping ^{[1
]}

Zhao, Wanting ^{[1
]}

Andrews, Nancy C. ^{[2
]}

Chen, Jane-Jane ^{[1
]}

机构：

[1] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[2] Harvard Med Sch, Div Hematol Oncol, Childrens Hosp Boston, Boston, MA 02115 USA

来源：

HAEMATOLOGICA | 2008年 / 93卷 / 05期

关键词：

heme-regulated eIF2 alpha kinase; hepcidin; iron deficiency;

D O I：

10.3324/haematol.12175

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heme-regulated eIF2 alpha kinase (HRI) is essential for regulating globin translation in iron deficiency and in beta-thalassemia. We investigated the role of heme-regulated eIF2 alpha kinase in hemoglobin and red blood cell production as well as in iron homeostasis in a mouse model of iron overload. We show that HRI deficiency does not significantly affect red cell parameters of hemochromatosis (HFE-/(-)) mice. Importantly, heme-regulated eIF2 alpha kinase deficiency exacerbates decreases in hepcidin expression and splenic macrophage iron in HFE-/(-) mice. Furthermore, the serum level of bone morphogenic protein 2, which positively regulates hepcidin, is reduced in heme-regulated eIF2 alpha kinase deficiency, but not in HFE deficiency.

引用

页码：753 / 756

页数：4

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