Efficacy of Traditional Chinese Medicine in Xerostomia and Quality of Life during Radiotherapy for Head and Neck Cancer: A Prospective Pilot Study

被引：19

作者：

Hsu, Pei-Yu ^{[1
]}

Yang, Sien-Hung ^{[1
,2
]}

Tsang, Ngan-Ming ^{[2
,3
]}

Fan, Kang-Hsing ^{[3
]}

Hsieh, Chia-Hsun ^{[4
,5
]}

Lin, Jr-Rung ^{[6
,7
]}

Hong, Ji-Hong ^{[3
,8
]}

Lin, Yung-Chang ^{[4
,9
]}

Chen, Hsing-Yu ^{[1
]}

Yang, Cheng-Tao ^{[1
]}

Yang, Ching-Wei ^{[1
]}

Chen, Jiun-Liang ^{[1
,2
]}

机构：

[1] Taoyuan Chang Gung Mem Hosp, Div Chinese Internal Med, Dept Tradit Chinese Med, Taoyuan 33378, Taiwan

[2] Chang Gung Univ, Sch Chinese Med, Taoyuan 33302, Taiwan

[3] Linkou Chang Gung Mem Hosp, Dept Radiat Oncol, Taoyuan 33305, Taiwan

[4] Linkou Chang Gung Mem Hosp, Div Hematol Oncol, Dept Internal Med, Taoyuan 33305, Taiwan

[5] Chang Gung Univ, Dept Chem & Mat Engn, Taoyuan 33302, Taiwan

[6] Chang Gung Univ, Clin Informat & Med Stat Res Ctr, Taoyuan 33302, Taiwan

[7] Chang Gung Univ, Grad Inst Clin Med, Taoyuan 33302, Taiwan

[8] Chang Gung Univ, Coll Med, Dept Med Imaging & Radiol Sci, Taoyuan 33302, Taiwan

[9] Chang Gung Univ, Coll Med, Taoyuan 33302, Taiwan

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2016年 / 2016卷

关键词：

RADIATION-INDUCED XEROSTOMIA; HUMAN-PAPILLOMAVIRUS; CARCINOMA; THERAPY; IMPACT; COMPLEMENTARY; EPIDEMIOLOGY; CHEMOTHERAPY; HYPOFUNCTION; SURVIVAL;

D O I：

10.1155/2016/8359251

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Xerostomia is one of the most common acute and late complications of radiotherapy for head and neck cancer, and it affects quality of life. We conducted a prospective study to evaluate the efficacy of traditional Chinese medicine (TCM) in toxicities and quality of life during radiotherapy. Head and neck cancer patients who were scheduled for radiotherapy were checked for inclusion/exclusion criteria before enrollment. Patients in the study group (inpatients) were hospitalized in a Chinese medicine ward and received concomitant TCM intervention during radiotherapy, while those in the control group (outpatients) received only conventional cancer treatments at the Western outpatient department. The primary end point was amelioration of postradiotherapy side effects. The secondary end points were quality of life during the cancer therapy and occurrence of adverse events following the TCM treatments. Thirty inpatients and 50 outpatients completed the study. Compared to the control group, those in the TCM group had decreased severity of xerostomia. There was no treatment-related impairment of renal or hepatic function among TCM group. Although better outcomes of social contact, dyspnea, physical and emotional function, and financial problems were found in the TCM group, we need further confirmation about the impact of hospitalization itself on these results.

引用

页数：10

共 36 条

[1] THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].