Stability of ciprofloxacin and norfloxacin in the presence and absence of metal ions in acidic solution

被引：10

作者：

Hubicka, Urszula ^{[1
]}

Krzek, Jan ^{[1
]}

Walczak, Maria ^{[2
]}

机构：

[1] Jagiellonian Univ, Coll Med, Dept Inorgan & Analyt Chem, PL-30688 Krakow, Poland

[2] Jagiellonian Univ, Coll Med, Dept Pharmacokinet & Phys Pharm, PL-30688 Krakow, Poland

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2010年 / 15卷 / 05期

关键词：

Ciprofloxacin; norfloxacin; stability; metal ions; TLC; QUINOLONE; ANTIBACTERIAL; COMPLEXATION; AGENTS;

D O I：

10.3109/10837450903338379

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A thin-layer chromatographic-densitometric method was used to determine the stability of ciprofloxacin and norfloxacin in the presence and absence of metal ions in acidic solutions at 22 C, 50 C and 90 C. The degradation of ciprofloxacin and norfloxacin followed first order reaction kinetics in presence of metal ions. The extent of this degradation however depended on the type of metal ion and temperature. Product structures of ciprofloxacin (1-cyclopropyl-6-fluoro-7-(piperazin-1-yl)quinolin-4(1H)-one) and norfloxacin (1-ethyl-6-fluoro-7-(piperazin-1-yl) quinolin-4(1H)-one) were determined by analysis of UV spectra and using LC-MS method.

引用

页码：532 / 544

页数：13

共 50 条

[41] Spectrofluorimetric study of the acid-base equilibria and complexation behavior of the fluoroquinolone antibiotics ofloxacin, norfloxacin, ciprofloxacin and pefloxacin in aqueous solution [J].

Drakopoulos, AI ;

Ioannou, PC .

ANALYTICA CHIMICA ACTA, 1997, 354 (1-3) :197-204

[42] Study of the chemical chelates and anti-microbial effect of some metal ions in nanostructural form on the efficiency of antibiotic therapy "norfloxacin drug" [J].

Refat, Moamen S. ;

El-Hawary, W. F. ;

Mohamed, Mahmoud A. .

JOURNAL OF MOLECULAR STRUCTURE, 2012, 1013 :45-54

[43] Binding Effect of Common Ions to Human Serum Albumin in the Presence of Norfloxacin: Investigation with Spectroscopic and Zeta Potential Approaches [J].

Behnaz Bakaeean ;

Mona Kabiri ;

Hedieh Iranfar ;

Mohammad Reza Saberi ;

Jamshidkhan Chamani .

Journal of Solution Chemistry, 2012, 41 :1777-1801

[44] Rheology and Stability of Beverage Emulsions in the Presence and Absence of Weighting Agents: A Review [J].

Ali R. Taherian ;

Patrick Fustier ;

Michel Britten ;

Hosahalli S. Ramaswamy .

Food Biophysics, 2008, 3 :279-286

[45] Rheology and stability of beverage emulsions in the presence and absence of weighting agents: A review [J].

Taherian, Ali R. ;

Fustier, Patrick ;

Britten, Michel ;

Ramaswamy, Hosahalli S. .

FOOD BIOPHYSICS, 2008, 3 (03) :279-286

[46] Study of interaction between human serum albumin and Norfloxacin in the presence of counter ions using synchronous fluorescence spectroscopy [J].

Bakaeian, Behnaz ;

Saberi, Mohammad Reza ;

Chamani, Jamshid Khan .

CLINICAL BIOCHEMISTRY, 2011, 44 (13) :S170-S170

[47] Study on bubble penetrating solution/frother interface in the presence of ions [J].

Zhu, Hongzheng ;

Zhang, Yong ;

Pan, Gaochao ;

Yang, Fan ;

Chen, Jun ;

Min, Fanfei ;

Zhu, Jinbo .

POWDER TECHNOLOGY, 2022, 398

[48] Insights into aquatic toxicities of the antibiotics oxytetracycline and ciprofloxacin in the presence of metal: Complexation versus mixture [J].

Zhang, Yu ;

Cai, Xiyun ;

Lang, Xianming ;

Qiao, Xianliang ;

Li, Xuehua ;

Chen, Jingwen .

ENVIRONMENTAL POLLUTION, 2012, 166 :48-56

[49] Nanoplatelet interactions in the presence of multivalent ions: The effect of overcharging and stability [J].

Jansson, Maria ;

Belic, Domagoj ;

Forsman, Jan ;

Skepo, Marie .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2020, 579 :573-581

[50] Influences of pH and metal ions on the interactions of oxytetracycline onto nano-hydroxyapatite and their co-adsorption behavior in aqueous solution [J].

Yuan, Lei ;

Yan, Ming ;

Huang, Zhenzhen ;

He, Kai ;

Zeng, Guangming ;

Chen, Anwei ;

Hu, Liang ;

Li, Hui ;

Peng, Min ;

Huang, Tiantian ;

Chen, Guiqiu .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2019, 541 :101-113

← 1 2 3 4 5 →