Stability of ciprofloxacin and norfloxacin in the presence and absence of metal ions in acidic solution

被引：9

作者：

Hubicka, Urszula ^{[1
]}

Krzek, Jan ^{[1
]}

Walczak, Maria ^{[2
]}

机构：

[1] Jagiellonian Univ, Coll Med, Dept Inorgan & Analyt Chem, PL-30688 Krakow, Poland

[2] Jagiellonian Univ, Coll Med, Dept Pharmacokinet & Phys Pharm, PL-30688 Krakow, Poland

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2010年 / 15卷 / 05期

关键词：

Ciprofloxacin; norfloxacin; stability; metal ions; TLC; QUINOLONE; ANTIBACTERIAL; COMPLEXATION; AGENTS;

D O I：

10.3109/10837450903338379

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A thin-layer chromatographic-densitometric method was used to determine the stability of ciprofloxacin and norfloxacin in the presence and absence of metal ions in acidic solutions at 22 C, 50 C and 90 C. The degradation of ciprofloxacin and norfloxacin followed first order reaction kinetics in presence of metal ions. The extent of this degradation however depended on the type of metal ion and temperature. Product structures of ciprofloxacin (1-cyclopropyl-6-fluoro-7-(piperazin-1-yl)quinolin-4(1H)-one) and norfloxacin (1-ethyl-6-fluoro-7-(piperazin-1-yl) quinolin-4(1H)-one) were determined by analysis of UV spectra and using LC-MS method.

引用

页码：532 / 544

页数：13

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