Absolute monocyte/lymphocyte count prognostic score is independent of immunohistochemically determined cell of origin in predicting survival in diffuse large B-cell lymphoma

被引：47

作者：

Porrata, Luis F. ^{[1
]}

Ristow, Kay ^{[1
]}

Habermann, Thomas M. ^{[1
]}

Ozsan, Nazan ^{[3
]}

Dogan, Ahmet ^{[2
]}

Macon, William ^{[2
]}

Colgan, Joseph P. ^{[1
]}

Witzig, Thomas E. ^{[1
]}

Inwards, David J. ^{[1
]}

Ansell, Stephen M. ^{[1
]}

Micallef, Ivana N. ^{[1
]}

Johnston, Patrick B. ^{[1
]}

Nowakowski, Grzegorz S. ^{[1
]}

Thompson, Carrie ^{[1
]}

Markovic, Svetomir N. ^{[1
]}

机构：

[1] Mayo Clin, Div Hematol, Dept Med, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA

[3] Ege Univ, Dept Pathol, Izmir, Turkey

来源：

LEUKEMIA & LYMPHOMA | 2012年 / 53卷 / 11期

关键词：

Lymphoma and Hodgkin disease; survival; monocyte/lymphocyte prognostic score; NON-HODGKINS-LYMPHOMA; RITUXIMAB ERA; EXPRESSION; CHEMOTHERAPY; IMMUNOCHEMOTHERAPY; SUBTYPES; MODELS; TUMOR; CHOP;

D O I：

10.3109/10428194.2012.690605

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The absolute monocyte/lymphocyte count prognostic score (AMC/ALC score) has not been directly compared with the cell of origin (COO) to predict overall survival (OS) and progression-free survival (PFS) in diffuse large B-cell lymphoma (DLBCL). Thus, we retrospectively examined a new cohort of 99 patients with DLBCL treated from 2008 to 2010, (1) to validate whether AMC/ALC score affects survival, (2) to investigate whether AMC/ALC score is independent of COO to predict survival and (3) to assess whether AMC/ALC score can further stratify clinical outcomes by COO. By univariate analysis, the AMC/ALC score was a predictor for OS and PFS. On multivariate analysis performed including the COO and the International Prognostic Index, AMC/ALC score remained an independent predictor for OS and PFS. The AMC/ALC score was able to further stratify DLBCL clinical outcomes by COO. The AMC/ALC score was independent of COO and added to its ability to identify patients with high-risk disease.

引用

页码：2159 / 2165

页数：7

共 25 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment [J].

Alizadeh, Ash A. ;

Gentles, Andrew J. ;

Alencar, Alvaro J. ;

Liu, Chih Long ;

Kohrt, Holbrook E. ;

Houot, Roch ;

Goldstein, Matthew J. ;

Zhao, Shuchun ;

Natkunam, Yasodha ;

Advani, Ranjana H. ;

Gascoyne, Randy D. ;

Briones, Javier ;

Tibshirani, Robert J. ;

Myklebust, June H. ;

Plevritis, Sylvia K. ;

Lossos, Izidore S. ;

Levy, Ronald .

BLOOD, 2011, 118 (05) :1350-1358

[3]

[Anonymous], 1993, N ENGL J MED, V329, P987

[4] CD4+T-cell immune response to large B-cell non-Hodgkin's lymphoma predicts patient outcome [J].

Ansell, SM ;

Stenson, M ;

Habermann, TM ;

Jelinek, DF ;

Witzig, TE .

JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (03) :720-726

[5] Prognostic models for diffuse large B-cell lymphoma in the rituximab era: a never-ending story [J].

Bari, A. ;

Marcheselli, L. ;

Sacchi, S. ;

Marcheselli, R. ;

Pozzi, S. ;

Ferri, P. ;

Balleari, E. ;

Musto, P. ;

Neri, S. ;

Spiriti, M. A. Aloe ;

Cox, M. C. .

ANNALS OF ONCOLOGY, 2010, 21 (07) :1486-1491

[6] CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. [J].

Coiffier, B ;

Lepage, E ;

Brière, J ;

Herbrecht, R ;

Tilly, H ;

Bouabdallah, R ;

Morel, P ;

Van den Neste, E ;

Salles, G ;

Gaulard, P ;

Reyes, F ;

Gisselbrecht, C .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (04) :235-242

[7] EVALUATION OF THE COULTER-COUNTER MODEL S-PLUS-IV [J].

COX, CJ ;

HABERMANN, TM ;

PAYNE, BA ;

KLEE, GG ;

PIERRE, RV .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1985, 84 (03) :297-306

[8]

COX DR, 1972, J R STAT SOC B, V34, P187

[9] Absolute lymphocyte count is a prognostic factor in diffuse large B-cell lymphoma [J].

Cox, M. Christina ;

Nofroni, Italo ;

La Verde, Giacinto ;

Ferrari, Antonella ;

Amodeo, Rachele ;

Tatarelli, Caterina ;

Saltarelli, Francesca ;

Veggia, Barbara ;

Aloe-Spiriti, M. Antonietta ;

Ruco, Luigi ;

Monarca, Bruno .

BRITISH JOURNAL OF HAEMATOLOGY, 2008, 141 (02) :265-268

[10] Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells [J].

Dave, SS ;

Wright, G ;

Tan, B ;

Rosenwald, A ;

Gascoyne, RD ;

Chan, WC ;

Fisher, RI ;

Braziel, RM ;

Rimsza, LM ;

Grogan, TM ;

Miller, TP ;

LeBlanc, M ;

Greiner, TC ;

Weisenburger, DD ;

Lynch, JC ;

Vose, J ;

Armitage, JO ;

Smeland, EB ;

Kvaloy, S ;

Holte, H ;

Delabie, J ;

Connors, JM ;

Lansdorp, PM ;

Ouyang, Q ;

Lister, TA ;

Davies, AJ ;

Norton, AJ ;

Muller-Hermelink, HK ;

Ott, G ;

Campo, E ;

Montserrat, E ;

Wilson, WH ;

Jaffe, ES ;

Simon, R ;

Yang, LM ;

Powell, J ;

Zhao, H ;

Goldschmidt, N ;

Chiorazzi, M ;

Staudt, LM .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (21) :2159-2169

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