First total synthesis of astin G

被引：11

作者：

Schumacher, KK

Hauze, DB

Jiang, JJ

Szewczyk, J

Reddy, RE

Davis, FA

Joullié, MM ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

[2] Abbott Labs, Abbott Pk, IL 60064 USA

[3] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 03期

基金：

美国国家科学基金会;

关键词：

peptides; amino acids and derivatives; macrocycles;

D O I：

10.1016/S0040-4039(98)02423-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The astin family of cyclopentapeptides contains several noncoded amino acids, including beta-phenylalanine, alpha-aminobutyric acid and several substituted prolines. The difficult cyclization of the macrocycle and the subsequent first total synthesis of a member of this family, astin G, are discussed herein. This synthesis provides a model for the syntheses of the astins which contain the highly sensitive 3,4-dichloroproline. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：455 / 458

页数：4

共 30 条

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