Transmitted raltegravir resistance in an HIV-1 CRF_AG-infected patient

被引：59

作者：

Boyd, Sarita D. ^{[1
,2
]}

Maldarelli, Frank ^{[3
]}

Sereti, Irini ^{[1
]}

Ouedraogo, G. Laissa ^{[1
,2
]}

Rehm, Catherine A. ^{[1
]}

Boltz, Valerie ^{[3
]}

Shoemaker, Diana ^{[1
]}

Pau, Alice K. ^{[1
]}

机构：

[1] NIAID, NIH, Bethesda, MD 20892 USA

[2] SAIC Frederick Inc, Frederick, MD USA

[3] NCI, HIV Drug Resistance Program, NIH, Bethesda, MD 20892 USA

来源：

ANTIVIRAL THERAPY | 2011年 / 16卷 / 02期

基金：

美国国家卫生研究院;

关键词：

ANTIRETROVIRAL DRUG-RESISTANCE; REVERSE-TRANSCRIPTASE; INTEGRASE INHIBITORS; MUTATIONS; NAIVE; THERAPY; SUSCEPTIBILITY; INDIVIDUALS; PREVALENCE; CITIES;

D O I：

10.3851/IMP1749

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Here, we describe an HIV-infected patient with pretreatment resistance to raltegravir, nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors, and the ultimate ability to achieve viral suppression. Pretreatment integrase resistance testing is not routinely performed because transmitted integrase mutations conferring resistance to raltegravir are currently thought to be negligible. We suggest obtaining a pretreatment integrase genotype in patients with transmitted multiclass drug resistance in order to create an optimal first regimen and increase the chance for virological suppression.

引用

页码：257 / 261

页数：5

共 22 条

[1] Polymorphism in protease and reverse transcriptase and phenotypic drug resistance of HIV-1 recombinant CRFO2_AG isolates from patients with no prior use of Antiretroviral drugs in Abidjan, Cote d'Ivoire [J].

Adjé-Touré, C ;

Bilé, CE ;

Borget, MY ;

Hertog, K ;

Maurice, C ;

Nolan, ML ;

Nkengasong, JN .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2003, 34 (01) :111-113

[2]

[Anonymous], 2010, PREZ DAR PACK INS 20

[3] Raltegravir Plasma Concentrations in Treatment-Experienced Patients Receiving Salvage Regimens Based on Raltegravir With and Without Maraviroc Coadministration [J].

Baroncelli, Silvia ;

Villani, Paola ;

Weimer, Liliana E. ;

Ladisa, Nicoletta ;

Francisci, Daniela ;

Tommasi, Chiara ;

Vullo, Vincenzo ;

Preziosi, Roberta ;

Cicalini, Stefania ;

Cusato, Maria ;

Galluzzo, Clementina M. ;

Floridia, Marco ;

Regazzi, Mario .

ANNALS OF PHARMACOTHERAPY, 2010, 44 (05) :838-843

[4] Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update [J].

Bennett, Diane E. ;

Camacho, Ricardo J. ;

Otelea, Dan ;

Kuritzkes, Daniel R. ;

Fleury, Herve ;

Kiuchi, Mark ;

Heneine, Walid ;

Kantor, Rami ;

Jordan, Michael R. ;

Schapiro, Jonathan M. ;

Vandamme, Anne-Mieke ;

Sandstrom, Paul ;

Boucher, Charles A. B. ;

van de Vijver, David ;

Rhee, Soo-Yon ;

Liu, Tommy F. ;

Pillay, Deenan ;

Shafer, Robert W. .

PLOS ONE, 2009, 4 (03)

[5] HIV-1 Reverse Transcriptase Drug-Resistance Mutations in Chronically Infected Individuals Receiving or Naive to HAART in Cameroon [J].

Burda, Sherri T. ;

Viswanath, Ragupathy ;

Zhao, Jiangqin ;

Kinge, Thompson ;

Anyangwe, Christopher ;

Tinyami, Erick T. ;

Haldar, Bijayesh ;

Powell, Rebecca L. R. ;

Jarido, Veronica ;

Hewlett, Indira K. ;

Nyambi, Phillipe N. .

JOURNAL OF MEDICAL VIROLOGY, 2010, 82 (02) :187-196

[6] Two Independent Epidemics of HIV in Maryland [J].

Carr, Jean K. ;

Osinusi, Anu ;

Flynn, Colin P. ;

Gilliam, Bruce L. ;

Maheshwari, Varun ;

Zhao, Richard Y. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2010, 54 (03) :297-303

[7] Secondary Integrase Resistance Mutations Found in HIV-1 Minority Quasispecies in Integrase Therapy-Naive Patients Have Little or No Effect on Susceptibility to Integrase Inhibitors [J].

Ceccherini-Silberstein, Francesca ;

Van Baelen, Kurt ;

Armenia, Daniele ;

Trignetti, Maria ;

Rondelez, Evelien ;

Fabeni, Lavinia ;

Scopelliti, Fernanda ;

Pollicita, Michela ;

Van Wesenbeeck, Liesbeth ;

Van Eygen, Veerle ;

Dori, Luca ;

Sarmati, Loredana ;

Aquaro, Stefano ;

Palamara, Guido ;

Andreoni, Massimo ;

Stuyver, Lieven J. ;

Perno, Carlo Federico .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (09) :3938-3948

[8] High frequency of integrase Q148R minority variants in HIV-infected patients naive of integrase inhibitors [J].

Charpentier, Charlotte ;

Laureillard, Didier ;

Piketty, Christophe ;

Tisserand, Pascaline ;

Batisse, Dominique ;

Karmochkine, Marina ;

Si-Mohamed, Ali ;

Weiss, Laurence .

AIDS, 2010, 24 (06) :867-873

[9] Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection [J].

Cooper, David A. ;

Steigbigel, Roy T. ;

Gatell, Jose M. ;

Rockstroh, Jurgen K. ;

Katlama, Christine ;

Yeni, Patrick ;

Lazzarin, Adriano ;

Clotet, Bonaventura ;

Kumar, Princy N. ;

Eron, Joseph E. ;

Schechter, Mauro ;

Markowitz, Martin ;

Loutfy, Mona R. ;

Lennox, Jeffrey L. ;

Zhao, Jing ;

Chen, Joshua ;

Ryan, Desmond M. ;

Rhodes, Rand R. ;

Killar, John A. ;

Gilde, Lucinda R. ;

Strohmaier, Kim M. ;

Meibohm, Anne R. ;

Miller, Michael D. ;

Hazuda, Daria J. ;

Nessly, Michael L. ;

DiNubile, Mark J. ;

Isaacs, Robin D. ;

Teppler, Hedy ;

Nguyen, Bach-Yen .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (04) :355-365

[10]

Department of Health and Human Services, PAN ANT GUID AD AD G

← 1 2 3 →