共 71 条
IL-6 Promotes Cardiac Graft Rejection Mediated by CD4+ Cells
被引:54
作者:

Booth, Adam Jared
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Med Ctr, Sect Transplantat Surg, Dept Internal Med,Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA

Grabauskiene, Svetlana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Sect Transplantat Surg, Dept Internal Med,Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA

Wood, Sherri Chan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Sect Transplantat Surg, Dept Internal Med,Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA

Lu, Guanyi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Sect Transplantat Surg, Dept Internal Med,Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA

Burrell, Bryna E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Sch Med, Ctr Vasc & Inflammatory Dis, Baltimore, MD 21201 USA Univ Michigan, Med Ctr, Sect Transplantat Surg, Dept Internal Med,Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA

Bishop, D. Keith
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Med Ctr, Sect Transplantat Surg, Dept Internal Med,Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA
Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Sect Transplantat Surg, Dept Internal Med,Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA
机构:
[1] Univ Michigan, Med Ctr, Sect Transplantat Surg, Dept Internal Med,Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA
[3] Univ Maryland, Sch Med, Ctr Vasc & Inflammatory Dis, Baltimore, MD 21201 USA
基金:
美国国家卫生研究院;
关键词:
HELPER T-LYMPHOCYTES;
TGF-BETA;
ALLOGRAFT-REJECTION;
ENDOTHELIAL-CELLS;
SOLUBLE RECEPTOR;
DENDRITIC CELLS;
CYTOKINE GENES;
IN-VIVO;
INDUCTION;
EXPRESSION;
D O I:
10.4049/jimmunol.1100766
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
IL-6 mediates numerous immunologic effects relevant to transplant rejection; however, its specific contributions to these processes are not fully understood. To this end, we neutralized IL-6 in settings of acute cardiac allograft rejection associated with either CD8(+) or CD4(+) cell-dominant responses. In a setting of CD8(+) cell-dominant graft rejection, IL-6 neutralization delayed the onset of acute rejection while decreasing graft infiltrate and inverting anti-graft Th1/Th2 priming dominance in recipients. IL-6 neutralization markedly prolonged graft survival in the setting of CD4(+) cell-mediated acute rejection and was associated with decreased graft infiltrate, altered Th1 responses, and reduced serum alloantibody. Furthermore, in CD4(+) cell-dominated rejection, IL-6 neutralization was effective when anti-IL-6 administration was delayed by as many as 6 d posttransplant. Finally, IL-6 deficient graft recipients were protected from CD4(+) cell-dominant responses, suggesting that IL-6 production by graft recipients, rather than grafts, is necessary for this type of rejection. Collectively, these observations define IL-6 as a critical promoter of graft infiltration and a shaper of T cell lineage development in cardiac graft rejection. In light of these findings, the utility of therapeutics targeting IL-6 should be considered for preventing cardiac allograft rejection. The Journal of Immunology, 2011, 187: 5764-5771.
引用
收藏
页码:5764 / 5771
页数:8
相关论文
共 71 条
[1]
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation:: Evidence in Crohn disease and experimental colitis in vivo
[J].
Atreya, R
;
Mudter, J
;
Finotto, S
;
Müllberg, J
;
Jostock, T
;
Wirtz, S
;
Schütz, M
;
Bartsch, B
;
Holtmann, M
;
Becker, C
;
Strand, D
;
Czaja, J
;
Schlaak, JF
;
Lehr, HA
;
Autschbach, F
;
Schürmann, G
;
Nishimoto, N
;
Yoshizaki, K
;
Ito, H
;
Kishimoto, T
;
Galle, PR
;
Rose-John, S
;
Neurath, MF
.
NATURE MEDICINE,
2000, 6 (05)
:583-588

Atreya, R
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Mudter, J
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Finotto, S
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Müllberg, J
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Jostock, T
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Wirtz, S
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Schütz, M
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Bartsch, B
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Holtmann, M
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Becker, C
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Strand, D
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Czaja, J
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Schlaak, JF
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Lehr, HA
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Autschbach, F
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Schürmann, G
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Nishimoto, N
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Yoshizaki, K
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Ito, H
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Kishimoto, T
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Galle, PR
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Rose-John, S
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

Neurath, MF
论文数: 0 引用数: 0
h-index: 0
机构:
Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany
[2]
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
[J].
Bettelli, E
;
Carrier, YJ
;
Gao, WD
;
Korn, T
;
Strom, TB
;
Oukka, M
;
Weiner, HL
;
Kuchroo, VK
.
NATURE,
2006, 441 (7090)
:235-238

Bettelli, E
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

Carrier, YJ
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

Gao, WD
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

Korn, T
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

Strom, TB
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

Oukka, M
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

Weiner, HL
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

Kuchroo, VK
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
[3]
MOBILIZATION OF LYMPHOCYTES-T FOLLOWING CARDIAC TRANSPLANTATION - EVIDENCE THAT CD4-POSITIVE CELLS ARE REQUIRED FOR CYTOTOXIC LYMPHOCYTE-T ACTIVATION, INFLAMMATORY ENDOTHELIAL DEVELOPMENT, GRAFT INFILTRATION, AND ACUTE ALLOGRAFT-REJECTION
[J].
BISHOP, DK
;
SHELBY, J
;
EICHWALD, EJ
.
TRANSPLANTATION,
1992, 53 (04)
:849-857

BISHOP, DK
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT SURG,SALT LAKE CITY,UT 84132

SHELBY, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT SURG,SALT LAKE CITY,UT 84132

EICHWALD, EJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT SURG,SALT LAKE CITY,UT 84132
[4]
CD4-POSITIVE HELPER T-LYMPHOCYTES MEDIATE MOUSE CARDIAC ALLOGRAFT-REJECTION INDEPENDENT OF DONOR ALLOANTIGEN-SPECIFIC CYTOTOXIC T-LYMPHOCYTES
[J].
BISHOP, DK
;
CHAN, S
;
LI, WH
;
ENSLEY, RD
;
XU, SX
;
EICHWALD, EJ
.
TRANSPLANTATION,
1993, 56 (04)
:892-897

BISHOP, DK
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT MED,DIV CARDIOL,SALT LAKE CITY,UT 84132

CHAN, S
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT MED,DIV CARDIOL,SALT LAKE CITY,UT 84132

LI, WH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT MED,DIV CARDIOL,SALT LAKE CITY,UT 84132

ENSLEY, RD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT MED,DIV CARDIOL,SALT LAKE CITY,UT 84132

XU, SX
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT MED,DIV CARDIOL,SALT LAKE CITY,UT 84132

EICHWALD, EJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT MED,DIV CARDIOL,SALT LAKE CITY,UT 84132
[5]
HELPER T-LYMPHOCYTE UNRESPONSIVENESS TO CARDIAC ALLOGRAFTS FOLLOWING TRANSIENT DEPLETION OF CD4-POSITIVE CELLS
[J].
BISHOP, DK
;
LI, WH
;
CHAN, SY
;
ENSLEY, RD
;
SHELBY, J
;
EICHWALD, EJ
.
TRANSPLANTATION,
1994, 58 (05)
:576-584

BISHOP, DK
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT PATHOL,SALT LAKE CITY,UT 84132

LI, WH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT PATHOL,SALT LAKE CITY,UT 84132

CHAN, SY
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT PATHOL,SALT LAKE CITY,UT 84132

ENSLEY, RD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT PATHOL,SALT LAKE CITY,UT 84132

SHELBY, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT PATHOL,SALT LAKE CITY,UT 84132

EICHWALD, EJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV UTAH,SCH MED,DEPT PATHOL,SALT LAKE CITY,UT 84132
[6]
Immunobiology of allograft rejection in the absence of IFN-γ:: CD8+ effector cells develop independently of CD4+ cells and CD40-CD40 ligand interactions
[J].
Bishop, DK
;
Wood, SC
;
Eichwald, EJ
;
Orosz, CG
.
JOURNAL OF IMMUNOLOGY,
2001, 166 (05)
:3248-3255

Bishop, DK
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Med Ctr, Sect Gen Surg, Dept Surg,Sch Med, Ann Arbor, MI 48109 USA

Wood, SC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Med Ctr, Sect Gen Surg, Dept Surg,Sch Med, Ann Arbor, MI 48109 USA

Eichwald, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Med Ctr, Sect Gen Surg, Dept Surg,Sch Med, Ann Arbor, MI 48109 USA

Orosz, CG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Med Ctr, Sect Gen Surg, Dept Surg,Sch Med, Ann Arbor, MI 48109 USA
[7]
IL-4 induces protection of vascular endothelial cells against killing by complement and melittin through lipid biosynthesis
[J].
Black, Sylvester M.
;
Schott, Megan E.
;
Batdorf, Bjorn H.
;
Benson, Barbara A.
;
Rutherford, Mark S.
;
Levay-Young, Brett K.
;
Dalmasso, Agustin P.
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
2010, 40 (03)
:803-812

Black, Sylvester M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA

Schott, Megan E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA

Batdorf, Bjorn H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA

Benson, Barbara A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA

Rutherford, Mark S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Coll Vet Med, St Paul, MN 55108 USA Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA

Levay-Young, Brett K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA

Dalmasso, Agustin P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA
Univ Minnesota, Dept Lab Med & Pathol, Sch Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Surg, Sch Med, Minneapolis, MN 55455 USA
[8]
Connective Tissue Growth Factor Promotes Fibrosis Downstream of TGFβ and IL-6 in Chronic Cardiac Allograft Rejection
[J].
Booth, A. J.
;
Csencsits-Smith, K.
;
Wood, S. C.
;
Lu, G.
;
Lipson, K. E.
;
Bishop, D. K.
.
AMERICAN JOURNAL OF TRANSPLANTATION,
2010, 10 (02)
:220-230

Booth, A. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Med Ctr, Grad Program Immunol, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Grad Program Immunol, Ann Arbor, MI 48109 USA

Csencsits-Smith, K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr Houston, Dept Pathol & Lab Med, Houston, TX USA Univ Michigan, Med Ctr, Grad Program Immunol, Ann Arbor, MI 48109 USA

Wood, S. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Grad Program Immunol, Ann Arbor, MI 48109 USA

Lu, G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Grad Program Immunol, Ann Arbor, MI 48109 USA

Lipson, K. E.
论文数: 0 引用数: 0
h-index: 0
机构:
FibroGen Inc, San Francisco, CA USA Univ Michigan, Med Ctr, Grad Program Immunol, Ann Arbor, MI 48109 USA

Bishop, D. K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Med Ctr, Grad Program Immunol, Ann Arbor, MI 48109 USA
Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Grad Program Immunol, Ann Arbor, MI 48109 USA
[9]
TGF-β, IL-6, IL-17 and CTGF direct multiple pathologies of chronic cardiac allograft rejection
[J].
Booth, Adam J.
;
Bishop, D. Keith
.
IMMUNOTHERAPY,
2010, 2 (04)
:511-520

Booth, Adam J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Div Pulm & Crit Care, Dept Internal Med, Med Ctr, Ann Arbor, MI 48109 USA Univ Michigan, Div Pulm & Crit Care, Dept Internal Med, Med Ctr, Ann Arbor, MI 48109 USA

Bishop, D. Keith
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Div Pulm & Crit Care, Dept Internal Med, Med Ctr, Ann Arbor, MI 48109 USA Univ Michigan, Div Pulm & Crit Care, Dept Internal Med, Med Ctr, Ann Arbor, MI 48109 USA
[10]
CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice
[J].
Burrell, Bryna E.
;
Csencsits, Keri
;
Lu, Guanyi
;
Grabauskiene, Svetlana
;
Bishop, D. Keith
.
JOURNAL OF IMMUNOLOGY,
2008, 181 (06)
:3906-3914

Burrell, Bryna E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Grad Program Immunol, Sch Med, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Sect Gen Surg, Transplant Immunol Res Lab,Dept Surg,Sch Med, Ann Arbor, MI 48109 USA

Csencsits, Keri
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Med Ctr, Sect Gen Surg, Transplant Immunol Res Lab,Dept Surg,Sch Med, Ann Arbor, MI 48109 USA

Lu, Guanyi
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Med Ctr, Sect Gen Surg, Transplant Immunol Res Lab,Dept Surg,Sch Med, Ann Arbor, MI 48109 USA

Grabauskiene, Svetlana
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Med Ctr, Sect Gen Surg, Transplant Immunol Res Lab,Dept Surg,Sch Med, Ann Arbor, MI 48109 USA

Bishop, D. Keith
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Med Ctr, Sect Gen Surg, Transplant Immunol Res Lab,Dept Surg,Sch Med, Ann Arbor, MI 48109 USA
Univ Michigan, Grad Program Immunol, Sch Med, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Sect Gen Surg, Transplant Immunol Res Lab,Dept Surg,Sch Med, Ann Arbor, MI 48109 USA