From in vitro to in vivo reprogramming for neural transdifferentiation: An approach for CNS tissue remodeling using stem cell technology

被引：7

作者：

Egawa, Naohiro ^{[1
,2
,3
]}

Suzuki, Hidefumi ^{[1
,2
,3
]}

Takahashi, Ryosuke ^{[1
]}

Hayakawa, Kazuhide ^{[4
,5
]}

Li, Wenlu ^{[4
,5
]}

Lo, Eng H. ^{[4
,5
]}

Arai, Ken ^{[4
,5
]}

Inoue, Haruhisa ^{[2
,3
,6
]}

机构：

[1] Kyoto Univ, Dept Neurol, Grad Sch Med, Kyoto, Japan

[2] RIKEN BioResource Res Ctr BRC, iPSC Based Drug Discovery & Dev Team, Kyoto, Japan

[3] Kyoto Univ, Ctr iPS Cell Res & Applicat CiRA, Kyoto, Japan

[4] Massachusetts Gen Hosp, Dept Radiol, Neuroprotect Res Labs, Boston, MA USA

[5] Massachusetts Gen Hosp, Dept Neurol, Neuroprotect Res Labs, Boston, MA 02114 USA

[6] RIKEN Ctr Adv Intelligence Project AIP, Med Risk Avoidance Based iPS Cells Team, Kyoto, Japan

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2020年 / 40卷 / 09期

关键词：

in vivo direct reprogramming; transdifferentiation; CNS injury; neurodegenerative disease; iPSC; HUMAN NEURONAL CELLS; HUMAN FIBROBLASTS; DIRECT CONVERSION; FUNCTIONAL-NEURONS; DOPAMINERGIC-NEURONS; MOUSE ASTROCYTES; GLIAL-CELLS; NG2; GLIA; OLIGODENDROCYTE; BRAIN;

D O I：

10.1177/0271678X20910324

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Advances in stem cell technology have provided three approaches to address the demanding issue of the treatment of intractable neurological disease. One of the approaches is the screening of compounds attenuating pathological phenotypes in stem-cell based models. A second approach consists of exogenous-targeted cell supplementation to the lesion with stem cell-derived differentiated cells. A third approach involves in vivo direct programming to transdifferentiate endogenous somatic cells and to boost CNS tissue remodeling. In this review, we outline research advances in stem cell technology of direct reprogramming in vitro and in vivo and discuss the future challenge of tissue remodeling by neural transdifferentiation.

引用

页码：1739 / 1751

页数：13

共 21 条

[21] The neuroprotective effect of rat adipose tissue-derived mesenchymal stem cell-conditioned medium on cortical neurons using an in vitro model of SCI inflammation
Szekiova, Eva
Slovinska, Lucia
Blasko, Juraj
Plsikova, Jana
Cizkova, Dasa
NEUROLOGICAL RESEARCH, 2018, 40 (04) : 258 - 267

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