Proteomics in Cancer Biomarkers Discovery: Challenges and Applications

被引:66
作者
Sallam, Reem M. [1 ,2 ,3 ]
机构
[1] King Saud Univ, Coll Med, Dept Pathol, Clin Chem Unit, Riyadh 11461, Saudi Arabia
[2] King Saud Univ, Coll Med, Obes Res Ctr, Riyadh 11461, Saudi Arabia
[3] Ain Shams Univ, Dept Med Biochem & Mol Biol, Fac Med, Cairo 11566, Egypt
关键词
OVARIAN-CANCER; MASS-SPECTROMETRY; TUMOR MICROENVIRONMENT; PROGNOSTIC BIOMARKER; PROTEIN BIOMARKERS; BREAST; ASCITES; SERUM; IDENTIFICATION; PATTERNS;
D O I
10.1155/2015/321370
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
With the introduction of recent high-throughput technologies to various fields of science and medicine, it is becoming clear that obtaining large amounts of data is no longer a problem in modern research laboratories. However, coherent study designs, optimal conditions for obtaining high-quality data, and compelling interpretation, in accordance with the evidence-based systems biology, are critical factors in ensuring the emergence of good science out of these recent technologies. This review focuses on the proteomics field and its new perspectives on cancer research. Cornerstone publications that have tremendously helped scientists and clinicians to better understand cancer pathogenesis; to discover novel diagnostic and/or prognostic biomarkers; and to suggest novel therapeutic targets will be presented. The author of this review aims at presenting some of the relevant literature data that helped as a step forward in bridging the gap between bench work results and bedside potentials. Undeniably, this review cannot include all the work that is being produced by expert research groups all over the world.
引用
收藏
页码:1 / 12
页数:12
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