QuEChERS Sample Preparation in the Simultaneous Determination of Residual Amounts of Quinolones, Sulfanilamides, and Amphenicols in Food Using HPLC with a Diode-Array Detector

被引：20

作者：

Amelin, V. G. ^{[1
]}

Volkova, N. M. ^{[1
,2
]}

Timofeev, A. A. ^{[1
,2
]}

Tret'yakov, A. V. ^{[2
]}

机构：

[1] Vladimir State Univ, Vladimir 600000, Russia

[2] Fed Ctr Anim Hlth, Vladimir 600901, Russia

来源：

JOURNAL OF ANALYTICAL CHEMISTRY | 2015年 / 70卷 / 09期

关键词：

antibiotics of quinolone series; sulfanilamides; amphenicols; food; HPLC; diode-array detector; LIQUID-CHROMATOGRAPHY; SCREENING METHOD; SULFONAMIDES; VALIDATION; EXTRACTION; OPTIMIZATION; ANTIBIOTICS; DRUGS;

D O I：

10.1134/S1061934815090026

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method is proposed for the simultaneous determination of antibiotics of quinolone series (enoxacin, danofloxacin, lomefloxacin, enrofloxacin, difloxacin, and oxolinic acid), sulfanilamides (sulfanilamide, sulfadiazine, sulfapyridine, sulfamerazine, sulfachloropyridazine, sulfadimethoxine, and sulfaquinoxaline), and amphenicols (chloramphenicol, florfenicol, and thiamphenicol) in foodstuffs by HPLC with diode-array detection at 228 and 280 nm from single weighed portion using a simplified, rapid, and safe QuEChERS sample preparation. The analytical range is 0.01-2 mg/kg for quinolones and 0.002-1 mg/kg for sulfanilamides and amphenicols at a sample weight of 5 g. The relative standard deviation of the results of analysis does not exceed 0.1. The time of analysis is 1-1.5 h.

引用

收藏

页码：1076 / 1084

页数：9

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