Microsatellite instability analysis in uterine cavity washings as a screening tool for endometrial cancer in Lynch syndrome

被引：6

作者：

Bouquier, Julie ^{[1
,2
]}

Blons, Helene ^{[2
,3
]}

Narjoz, Celine ^{[2
,3
]}

Lecuru, Fabrice ^{[1
,2
,4
]}

Laurent-Puig, Pierre ^{[2
,5
,6
]}

Bats, Anne-Sophie ^{[1
,2
,4
]}

机构：

[1] Hop Europe Georges Pompidou, AP HP, Serv Chirurg Gynecol & Cancerol, F-75015 Paris, France

[2] Univ Paris 05, Paris, France

[3] Hop Europe Georges Pompidou, AP HP, Serv Biochim, F-75015 Paris, France

[4] INSERM, UMR S 747, Paris, France

[5] Hop Europe Georges Pompidou, AP HP, Serv Genet, F-75015 Paris, France

[6] INSERM, UMR S775, Paris, France

来源：

FAMILIAL CANCER | 2011年 / 10卷 / 04期

关键词：

Lynch syndrome; Endometrial cancer; Screening; Microsatellite instability analysis; NONPOLYPOSIS COLORECTAL-CANCER; BLADDER; RECURRENCE; CARCINOMA; PATIENT; MARKER; URINE; HNPCC; MLH1; MSH2;

D O I：

10.1007/s10689-011-9470-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although patients with Lynch syndrome (LS) are at high risk of endometrial cancer, gynecologic screening has been poorly investigated and diagnostic value of current screening tests remains unclear. Microsatellite instability (MSI) phenotype is found in more than 90% of endometrial cancers developed in LS patients. Here we report the first two cases of unstable endometrial tumors with detection of MSI in uterine cavity washings cells. This new technique may be a promising screening tool in LS.

引用

收藏

页码：655 / 657

页数：3

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