Partial Normalization of Biomarkers of Inflammation and Immune Activation Among Virally Suppressed Men With HIV Infection and High ART Adherence

被引：18
作者：
Castillo-Mancilla, Jose R. [1 ]
Brown, Todd T. [2 ]
Palella, Frank J., Jr. [3 ]
Macatangay, Bernard J. C. [4 ]
Breen, Elizabeth C. [5 ]
Jacobson, Lisa P. [6 ]
Wada, Nikolas I. [6 ]
机构：
[1] Univ Colorado AMC, Sch Med, Div Infect Dis, Aurora, CO USA
[2] Johns Hopkins Univ, Sch Med, Div Endocrinol Diabet & Metab, Baltimore, MD USA
[3] Northwestern Univ, Div Infect Dis, Feinberg Sch Med, Chicago, IL 60611 USA
[4] Univ Pittsburgh, Sch Med, Div Infect Dis, HIV AIDS Unit, Pittsburgh, PA USA
[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2020年 / 7卷 / 04期
基金：
美国国家卫生研究院;
关键词：
adherence; antiretroviral therapy; HIV; inflammation; ANTIRETROVIRAL THERAPY; INTENSIFICATION;
D O I：
10.1093/ofid/ofaa099
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background. The objective of this study was to investigate whether 100% antiretroviral therapy (ART) adherence in men with HIV (MWH) is associated with normalization of concentrations of biomarkers of inflammation and immune activation compared with HIV-uninfected men. Methods. We analyzed person-visits with available biomarker data from the Multicenter AIDS Cohort Study (MACS) among MWH receiving ART with HIV RNA <50 copies/mL and among HIV-uninfected men. Self-reported adherence was classified as 100% if no missed ART doses in the past 4 days were reported. We evaluated associations between ART adherence and concentrations of 24 serum biomarkers compared with HIV-uninfected visits using a generalized gamma model, adjusting for potential confounders. Results. Person-visits (2565 from MWH reporting 100% ART adherence and 1588 from HIV-uninfected men) from a total of 1469 men were included in the analysis. Serum concentrations of interleukin-6 (IL-6), soluble interleukin-6 receptor (sIL-6R), IL-1 beta, interferon-gamma (IFN-gamma), chemokine C-C motif ligand 2 (CCL2), and CCL14 from person-visits among MWH who reported 100% adherence were similar to HIV-uninfected person-visits. Comparatively higher concentrations of 11 biomarkers and lower concentrations of 7 biomarkers were observed in person-visits from MWH who reported 100% ART adherence, compared with HIV-uninfected person-visits. Conclusions. Although MWH with virologic suppression who reported 100% ART adherence exhibited overall higher concentrations of biomarkers of inflammation and immune activation compared with HIV-uninfected men, some biomarker concentrations were similar in both groups. These findings suggest that optimal ART adherence could have clinical implications beyond achieving and sustaining viral suppression.
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