Red Blood Cell Transfusion in the Neurological ICU

被引:14
作者
Kumar, Monisha A. [1 ,2 ,3 ,4 ]
机构
[1] Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA
[3] Univ Penn, Perelman Sch Med, Dept Anesthesiol, Philadelphia, PA 19104 USA
[4] Univ Penn, Perelman Sch Med, Dept Crit Care, Philadelphia, PA 19104 USA
关键词
Anemia; Transfusion; ICU; Erythrocytes; Hemoglobin; Neurocritical care; ANEURYSMAL SUBARACHNOID HEMORRHAGE; ACUTE LUNG INJURY; TRAUMATIC BRAIN-INJURY; CRITICALLY-ILL PATIENTS; RANDOMIZED CONTROLLED-TRIAL; INDEPENDENT RISK FACTOR; HEMOGLOBIN CONCENTRATION; CEREBRAL OXYGENATION; CARDIAC-SURGERY; ACUTE STROKE;
D O I
10.1007/s13311-011-0094-5
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Red blood cell transfusion (RBCT) is a common therapy used in the intensive care unit to treat anemia. However, due to deleterious side effects and questionable efficacy, the clinical benefit of RBCT in patients who are not actively bleeding is unclear. The results of randomized controlled trials suggest there is no benefit to a liberal transfusion practice in general critical care populations. Whether the results of these trials are applicable to brain injured patients is unknown, as patients with primary neurological injury were excluded. This article reviews the efficacy and complications of RBCT, as well as the relationship between RBCT and its outcome in both the general intensive care unit and neurologically critically ill populations.
引用
收藏
页码:56 / 64
页数:9
相关论文
共 117 条
[1]  
AGARWAL N, 1993, ARCH SURG-CHICAGO, V128, P171
[2]   Elevated hematocrit is associated with reduced reperfusion and tissue survival in acute stroke [J].
Allport, LE ;
Parsons, MW ;
Butcher, KS ;
MacGregor, L ;
Desmond, PM ;
Tress, BM ;
Davis, SM .
NEUROLOGY, 2005, 65 (09) :1382-1387
[3]   EFFECT OF ERYTHROCYTE STORAGE AND OXYHEMOGLOBIN AFFINITY CHANGES ON CARDIAC-FUNCTION [J].
APSTEIN, CS ;
DENNIS, RC ;
BRIGGS, L ;
VOGEL, WM ;
FRAZER, J ;
VALERI, CR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (04) :H508-H515
[4]  
Asplund K., 2002, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD000103
[5]   Intraoperative Hemoglobin Levels and Transfusion Independently Predict Stroke After Cardiac Operations [J].
Bahrainwala, Zainab S. ;
Grega, Maura A. ;
Hogue, Charles W. ;
Baumgartner, William A. ;
Selnes, Ola A. ;
McKhann, Guy M. ;
Gottesman, Rebecca F. .
ANNALS OF THORACIC SURGERY, 2011, 91 (04) :1113-1118
[6]  
BAKER CH, 1986, CIRC SHOCK, V20, P127
[7]   Tracking TRALI in target populations [J].
Benjamin, Richard J. .
BLOOD, 2011, 117 (16) :4163-4164
[8]   Influence of storage on red blood cell rheological properties [J].
Berezina, TL ;
Zaets, SB ;
Morgan, C ;
Spillert, CR ;
Kamiyama, M ;
Spolarics, Z ;
Deitch, EA ;
Machiedo, GW .
JOURNAL OF SURGICAL RESEARCH, 2002, 102 (01) :6-12
[9]  
BEUTLER E, 1982, BLOOD, V59, P1141
[10]   Microparticle-mediated thrombin generation assay: increased activity in patients with recurrent thrombosis [J].
Bidot, L. ;
Jy, W. ;
Bidot, C. ;
Jimenez, J. J. ;
Fontana, V. ;
Horstman, L. L. ;
Ahn, Y. S. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2008, 6 (06) :913-919