On the differential diagnosis of Meniere's disease using low-frequency acoustic biasing of the 2f1-f2 DPOAE

We have cyclically suppressed the 2f1-12 distortion product otoacoustic emission (DPOAE) with low-frequency tones (17-97 Hz) as a way of differentially diagnosing the endolymphatic hydrops assumed to be associated with Meniere's syndrome. Round-window electrocochleography (ECochG) was performed in subjects with sensorineural hearing loss (SNHL) on the day of DPOAE testing, and from which the amplitude of the summating potential (SP) was measured, to support the diagnosis of Meniere's syndrome based on symptoms. To summarize and compare the cyclic patterns of DPOAE modulation in these groups we have used the simplest model of DPOAE generation and modulation, by assuming that the DPOAEs were generated by a 1st-order Boltzmann nonlinearity so that the magnitude of the 2f1-f2 DPOAE resembled the 3rd derivative cif the Boltzmann function. We have also assumed that the modulation of the DPOAEs by the low-frequency tones was simply due to a sinusoidal change in the operating point on the Boltzmann nonlinearity. We have found the cyclic DPOAE modulation to be different in subjects with Meniere's syndrome (n = 16) when compared to the patterns in normal subjects (n = 16) and in other control subjects with non-Meniere's SNHL and/or vestibular disorders (n = 13). The DPOAEs of normal and non-Meniere's ears were suppressed more during negative ear canal pressure than during positive ear canal pressure. By contrast, DPOAE modulation in Meniere's ears with abnormal ECochG was greatest during positive ear canal pressures. This test may provide a tool for diagnosing Meniere's in the early stages, and might be used to investigate the pathological mechanism underlying the hearing symptoms of this. syndrome. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.