The Effect of FOXP3+ Regulatory T Cells on Infectious and Inflammatory Diseases

被引：6
作者：
Bai, Yakun [1 ,2 ,3 ,4 ]
Gao, Fang [5 ]
Li, Dan [4 ]
Ji, Suyuan [4 ]
Zhang, Shuijun [1 ,2 ,3 ]
Guo, Wenzhi [1 ,2 ,3 ]
Li, Bin [4 ]
机构：
[1] Zhengzhou Engn Lab Organ Transplantat Tech & Appl, Zhengzhou, Henan, Peoples R China
[2] Henan Engn Technol Res Ctr Organ Transplantat, Zhengzhou, Henan, Peoples R China
[3] First Affiliated Hosp Zhengzhou, Dept Hepatobiliary & Pancreat Surg, Zhengzhou, Henan, Peoples R China
[4] Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Dept Immunol & Microbiol, Sch Med, 280 Chongqing South Rd, Shanghai 200025, Peoples R China
[5] Binzhou Peoples Hosp, Hlth Management Ctr, Binzhou, Shandong, Peoples R China
来源：
INFECTIOUS MICROBES & DISEASES | 2021年 / 3卷 / 04期
基金：
中国国家自然科学基金;
关键词：
FOXP3; infection; inflammatory disease; regulatory T cells; ATTENUATED LISTERIA-MONOCYTOGENES; HELICOBACTER-PYLORI; TREG CELLS; TGF-BETA; HIV-1; INFECTION; LEISHMANIA; EXPANSION; EXPRESSION; INDUCTION; IMMUNITY;
D O I：
10.1097/IM9.0000000000000070
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) contribute to the maintenance of immune homeostasis and tolerance in the body. The expression levels and functional stability of FOXP3 control the function and plasticity of Tregs. Tregs critically impact infectious diseases, especially by regulating the threshold of immune responses to pathogenic microorganisms. The functional regulatory mechanism and cell-specific surface markers of Tregs in different tissues and inflammatory microenvironments have been investigated in depth, which can provide novel ideas and strategies for immunotherapies targeting infectious diseases.
引用
收藏
页码：187 / 197
页数：11
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