Regio- and Enantioselective Decarboxylative Allylic Benzylation Enabled by Dual Palladium/Photoredox Catalysis

被引：33

作者：

Song, Changhua ^{[1
]}

Zhang, Hong-Hao ^{[1
]}

Yu, Shouyun ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Adv Organ Mat, Chem & Biomed Innovat Ctr ChemBIC,State Key Lab A, Nanjing 210023, Peoples R China

来源：

ACS CATALYSIS | 2022年 / 12卷 / 02期

基金：

中国国家自然科学基金;

关键词：

acids; dual catalysis; photoredox catalysis; decarboxylation; asymmetric allylic alkylation; VISIBLE-LIGHT PHOTOREDOX; ASYMMETRIC-SYNTHESIS; ALPHA-ALLYLATION; CARBOXYLIC-ACIDS; ARYL HALIDES; PALLADIUM; ALKYLATION; FUNCTIONALIZATION; DERIVATIVES; DIASTEREO;

D O I：

10.1021/acscatal.1c05461

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A decarboxylative allylic benzylation cocatalyzed by Pd/photoredox in a regio- and enantioselective manner has been achieved. Readily available aryl acetic acids are used as benzylic nucleophile equivalents without preactivation. This mild and atom-economical protocol expands the scope of coupling partners of allylic electrophiles. Vinyl epoxides could also go through this transformation smoothly, affording various chiral homoallylic alcohols bearing all-carbon quaternary stereocenters.

引用

页码：1428 / 1432

页数：5

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