Hysteresis In CaMKII activity: A Stochastic Model

被引：0

作者：

Arun, Anirudhan, V ^{[1
]}

Ranjith, G. ^{[1
]}

Omkumar, R. V. ^{[2
]}

机构：

[1] Sree Chitra Tirunal Inst Med Sci & Technol, Device Testing Lab, Trivandrum, Kerala, India

[2] Rajiv Gandhi Ctr Biotechnol, Mol Neurobiol, Trivandrum, Kerala, India

来源：

2014 INTERNATIONAL CONFERENCE ON ADVANCES IN COMPUTING, COMMUNICATIONS AND INFORMATICS (ICACCI) | 2014年

关键词：

CaMKII; hysteresis; bistability; stochastic model; DEPENDENT PROTEIN-KINASE; RECEPTOR; BISTABILITY; ACTIVATION; STORAGE; SWITCH;

D O I：

暂无

中图分类号：

TP301 [理论、方法];

学科分类号：

081202 ;

摘要：

Calcium/calmodulin dependent protein kinase II (CaMKII) plays a crucial role in the induction of Long Term Potentiation. Several mathematical models have been developed to predict the activity levels of CaMKII in the physiological condition and its molecular switch properties. This paper attempts to study the hysteresis property of CaMKII using a stochastic model. It was observed that hysteresis exists under physiological conditions, but the width of the hysteresis band depends on the concentration of protein phosphatase 1 (PPl). The hysteresis band was maximum at low concentrations of PPI and reduced with increasing concentrations of PPI. It was also observed that the number of phosphorylated subunits saturates beyond a threshold value of calcium signal.

引用

页码：440 / 444

页数：5

共 21 条

[1] Interaction with the NMDA receptor locks CaMKII in an active conformation [J].

Bayer, KU ;

De Koninck, P ;

Leonard, AS ;

Hell, JW ;

Schulman, H .

NATURE, 2001, 411 (6839) :801-805

[2] The versatility and universality of calcium signalling [J].

Berridge, MJ ;

Lipp, P ;

Bootman, MD .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (01) :11-21

[3] An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling [J].

Bradshaw, JM ;

Kubota, Y ;

Meyer, T ;

Schulman, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10512-10517

[4] A biophysical model of bidirectional synaptic plasticity: Dependence on AMPA and NMDA receptors [J].

Castellani, GC ;

Quinlan, EM ;

Cooper, LN ;

Shouval, HZ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (22) :12772-12777

[5] Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible [J].

Ferrell, JE ;

Xiong, W .

CHAOS, 2001, 11 (01) :227-236

[6] Molecular switches at the synapse emerge from receptor and kinase traffic [J].

Hayer, A ;

Bhalla, US .

PLOS COMPUTATIONAL BIOLOGY, 2005, 1 (02) :137-154

[7] Models of calmodulin trapping and CaM kinase II activation in a dendritic spine [J].

Holmes, WR .

JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 2000, 8 (01) :65-85

[8] Transient versus asymptotic dynamics of CaM kinase II: Possible roles of phosphatase [J].

Kubota, Y ;

Bower, JM .

JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 2001, 11 (03) :263-279

[9] Calcium Input Frequency, Duration and Amplitude Differentially Modulate the Relative Activation of Calcineurin and CaMKII [J].

Li, Lu ;

Stefan, Melanie I. ;

Le Novere, Nicolas .

PLOS ONE, 2012, 7 (09)

[10] The molecular basis of CaMKII function in synaptic and behavioural memory [J].

Lisman, J ;

Schulman, H ;

Cline, H .

NATURE REVIEWS NEUROSCIENCE, 2002, 3 (03) :175-190

← 1 2 3 →