Clinical Pharmacology of Statins: an Update

被引：28

作者：

Ferri, Nicola ^{[1
]}

Corsini, Alberto ^{[2
,3
]}

机构：

[1] Univ Padua, Dept Pharmaceut & Pharmacol Sci, Largo Egidio Meneghetti 2, I-35131 Padua, Italy

[2] Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy

[3] IRCCS Multimed, Milan, Italy

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2020年 / 22卷 / 07期

关键词：

Statins; PCSK9; Ezetimibe; Bempedoic acid; Evolocumab; Alirocumab; Inclisiran; DENSITY-LIPOPROTEIN CHOLESTEROL; LOWERING LDL CHOLESTEROL; 20-YEAR FOLLOW-UP; PRIMARY PREVENTION; CARDIOVASCULAR RISK; BEMPEDOIC ACID; 80; MG; THERAPY; METAANALYSIS; EFFICACY;

D O I：

10.1007/s11883-020-00844-w

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Purpose of ReviewStatins represent the cornerstone for the treatment of hypercholesterolemia, although muscle-related side effects and dysregulation of glucose metabolism have strongly limited their adherence and compliance especially in primary prevention therapy. The purpose of the present review is to provide the most recent evidence of the efficacy and safety of statins in monotherapy or combination with new lipid-lowering drugs.Recent FindingsRecent "life-long" analysis conducted on young familial hypercholesterolemia patients, elderly hypocholesterolemic subjects, and from a 20-year follow-up of randomized controlled trial (RCT) have been published confirming that the cardiovascular benefits of statin therapy, in patients for whom it is recommended by current guidelines, greatly outweigh the risks of side effects. In addition, recent therapies to be used in combination with statins have shown to increase the percentage of patients at goal for low-density lipoprotein - cholesterol (LDL-C) with a good safety profile. The cardiovascular (CV) benefits of monoclonal antibodies anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) and ezetimibe, in patients under statin therapy, have been proven by specific RCT, while we are still waiting for the results of bempedoic acid and the small-interfering RNA (si-RNA) anti-PCSK9 inclisiran.SummaryTaken together, the approval of new pharmacological agents to be used in combination with statins represents the future for a tailored therapy of cardiovascular disease patients.

引用

页数：9

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