Reducing Protein Corona Formation and Enhancing Colloidal Stability of Gold Nanoparticles by Capping with Silica Monolayers

被引:32
作者
Mosquera, Jesus [1 ,2 ]
Garcia, Isabel [1 ,2 ]
Henriksen-Lacey, Malou [1 ,2 ]
Gonzalez-Rubio, Guillermo [1 ,2 ]
Liz-Marzan, Luis M. [1 ,2 ,3 ]
机构
[1] CIC biomaGUNE, Paseo Miramon 182, Donostia San Sebastian 20014, Spain
[2] CIBER BBN, Paseo Miramon 182, Donostia San Sebastian 20014, Spain
[3] Basque Fdn Sci, Ikerbasque, Bilbao 48013, Spain
关键词
SELF-ASSEMBLED MONOLAYERS; CONDENSATION; DEGRADATION; HYDROLYSIS; DENSITY; SURFACE;
D O I
10.1021/acs.chemmater.8b04647
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A study demonstrated the reducing of protein corona (PC) formation and enhancing colloidal stability of gold nanoparticles (Au NP) by capping with silica monolayers. Au NP surface was needed to achieve silica monolayer formation. In a first attempt to have a high density ligand coverage around NS-1, an excess of 3-mercaptopropyltrimethoxysilane (MPTMS) was directly added to a Au NP hydrosol, but this resulted in immediate aggregation. The resulting trimethoxysilane moiety covering the surface of NS-3 was subsequently hydrolyzed by addition of 5 mM NaOH in a 2:1 methanol/water mixture, yielding a polymeric monolayer.
引用
收藏
页码:57 / 61
页数:5
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