Complicated Pneumococcal Meningitis in a Fully Vaccinated Child: Value of Magnetic Resonance Imaging Monitoring

被引：2

作者：

Ilia, S. ^{[1
]}

Spanaki, A. -M. ^{[1
]}

Raissaki, M. ^{[2
]}

Spoulou, V. I. ^{[3
]}

Fitrolaki, M. -D. ^{[1
]}

Kanariou, M. ^{[4
]}

Tzanakaki, G. ^{[5
]}

Briassoulis, G. ^{[1
]}

机构：

[1] Univ Hosp Heraklion, Pediat Intens Care Unit, Iraklion 71003, Crete, Greece

[2] Univ Hosp Heraklion, Dept Radiol, Iraklion 71003, Crete, Greece

[3] Univ Athens, Sch Med, Dept Pediat 1, Div Infect Dis,Aghia Sophia Childrens Hosp, GR-11527 Athens, Greece

[4] Aghia Sophia Childrens Hosp, Dept Immunol Histocompatibil, Athens, Greece

[5] Natl Sch Publ Hlth, Natl Meningitis Reference Lab, Athens, Greece

来源：

NEUROPEDIATRICS | 2011年 / 42卷 / 06期

关键词：

meningitis; magnetic resonance imaging; pulse of steroids; vasculitis; Streptococcus pneumonia; PCV7; STREPTOCOCCUS-PNEUMONIAE; BACTERIAL-MENINGITIS; MENINGOENCEPHALITIS; VASCULOPATHY;

D O I：

10.1055/s-0031-1295407

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present a unique case of life-threatening pneumococcal meningitis complicated by vasculitis in a fully vaccinated 4-year-old female with the heptavalent conjugate vaccine for Streptococcus pneumoniae (PCV7). Serotype 23F was isolated in both blood and cerebral spinal fluid (CSF) samples. Pulses of methylprednisolone were promptly initiated in addition to antibiotics leading to a good recovery. CSF studies and magnetic resonance imaging (MRI) of the brain were used for diagnosis and monitoring the response to corticoid therapy. We report the investigations of a child with failure of PCV7 vaccine to protect against vaccine-serotype invasive disease. Use of corticosteroids and temporal association with changes in brain imaging are described for the first time in literature.

引用

页码：240 / 244

页数：5

共 13 条

[1] Influenza A Encephalopathy, Cerebral Vasculopathy, and Posterior Reversible Encephalopathy Syndrome: Combined Occurrence in a 3-Year-Old Child [J].

Bartynski, W. S. ;

Upadhyaya, A. R. ;

Petropoulou, K. A. ;

Boardman, J. F. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2010, 31 (08) :1443-1446

[2] Corticosteroids for acute bacterial meningitis [J].

Brouwer, Matthijs C. ;

McIntyre, Peter ;

de Gans, Jan ;

Prasad, Kameshwar ;

van de Beek, Diederik .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2010, (09)

[3] Prevenar™ vaccination:: Review of the global data, 2006 [J].

Center, Kimberly J. .

VACCINE, 2007, 25 (16) :3085-3089

[4] Severe, widespread vasculopathy in late-onset group B streptococcal meningitis [J].

Iijima, Shigeo ;

Shirai, Masami ;

Ohzeki, Takehiko .

PEDIATRICS INTERNATIONAL, 2007, 49 (06) :1000-1003

[5] Childhood encephalitis in Crete, Greece [J].

Ilias, Anestis ;

Galanakis, Emmanouil ;

Raissaki, Maria ;

Kalmanti, Maria .

JOURNAL OF CHILD NEUROLOGY, 2006, 21 (10) :910-912

[6] Meningoencephalitis caused by Streptococcus pneumoniae:: a diagnostic and therapeutic challenge -: Diagnosis with diffusion-weighted MRI leading to treatment with corticosteroids [J].

Jorens, PG ;

Parizel, PM ;

Demey, HE ;

Smets, K ;

Jadoul, K ;

Verbeek, MM ;

Wevers, RA ;

Cras, P .

NEURORADIOLOGY, 2005, 47 (10) :758-764

[7] Streptococcus pneumoniae meningoencephalitis with unusual and widespread white matter lesions [J].

Jorens, Philippe G. ;

Parizel, Paul M. ;

Wojciechowski, Marek ;

Laridon, Annick ;

De Weerdt, Annick ;

Mertens, Geert ;

Ceulemans, Berten .

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, 2008, 12 (02) :127-132

[8] Pneumococcal conjugate vaccines for preventing vaccine-type invasive pneumococcal disease and X-ray defined pneumonia in children less than two years of age [J].

Lucero, Marilla G. ;

Dulalia, Vernoni E. ;

Nillos, Leilani T. ;

Williams, Gail ;

Parrefio, Rhea Angela N. ;

Nohynek, Hanna ;

Riley, Ian D. ;

Makela, Helena .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2009, (04)

[9]

Marchioni E, 2008, NEUROL SCI, V29, pS286, DOI [10.1007/s11908-008-0050-7, 10.1007/s10072-008-0966-6]

[10] Serious neurologic sequelae in cases of meningitis arising from infection by conjugate vaccine-related and nonvaccine-related serogroups of Streptococcus pneumoniae [J].

Rajasingham, Christiana R. ;

Bonsu, Bema K. ;

Chapman, Jennifer I. ;

Cohen, Daniel M. ;

Barson, Williani J. .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2008, 27 (09) :771-775

← 1 2 →