Tumor infiltrating lymphocytes expressing membrane-bound IL-2 and IL-12 exhibit enhanced proliferation, function, and persistence without requiring exogenous IL-2 support

被引：0
|
作者：
Silver, R. J. [1 ]
Silva, M. [1 ]
Maloney, M. F. [2 ]
Brate, A. A. [2 ]
El-Sayes, N. [2 ]
Ozay, E. I. [2 ]
Parwanda, D. [1 ]
Bartlett, C. [1 ]
Sharei, A. [2 ]
Loughhead, S. M. [2 ]
Gilbert, J. [1 ]
Bridgen, D. T. [1 ]
机构：
[1] SQZ Biotechnol, Exploratory, Watertown, MA USA
[2] SQZ Biotechnol, R&D, Watertown, MA USA
来源：
ANNALS OF ONCOLOGY | 2022年 / 33卷 / 07期
关键词：
D O I：
10.1016/j.annonc.2022.07.887
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
761P
引用
收藏
页码：S891 / S891
页数：1
相关论文
共 50 条
  • [1] CLINICAL USE OF IL-2 ACTIVATED TUMOR-INFILTRATING LYMPHOCYTES AND IL-2 IN THE TREATMENT OF METASTATIC CANCER
    KRADIN, R
    BOYLE, L
    GROVE, B
    MULLIN, J
    STRAUSS, W
    CALLAHAN, R
    PREFFER, F
    DUBINETT, S
    KURNICK, J
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1987, 28 : 364 - 364
  • [2] CLINICAL USE OF IL-2 ACTIVATED TUMOR-INFILTRATING LYMPHOCYTES AND IL-2 IN THE TREATMENT OF METASTATIC CANCER
    KRADIN, R
    STRAUSS, W
    KURNICK, J
    CLINICAL RESEARCH, 1987, 35 (03): : A629 - A629
  • [3] IL-2 limits IL-12 enhanced lymphocyte proliferation during Leishmania amazonensis infection
    Ramer-Tait, Amanda E.
    Petersen, Christine A.
    Jones, Douglas E.
    CELLULAR IMMUNOLOGY, 2011, 270 (01) : 32 - 39
  • [4] Whole Tumor Cell Vaccine Adjuvants: Comparing IL-12 to IL-2 and IL-15
    Sheikhi, Abdolkarim
    Jafarzadeh, Abdollah
    Kokhaei, Parviz
    Hojjat-Farsangi, Mohammad
    IRANIAN JOURNAL OF IMMUNOLOGY, 2016, 13 (03) : 148 - 166
  • [5] MethA fibrosarcoma cells expressing membrane-bound forms of IL-2 enhance antitumor immunity
    Sonn, Chung Hee
    Yoon, Hee Ryung
    Seong, In Ock
    Chang, Mi-Ra
    Kim, Yong Chan
    Kang, Han-Chul
    Suh, Seok-Cheol
    Kim, Young Sang
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2006, 16 (12) : 1919 - 1927
  • [6] FUNCTIONAL-ROLE OF IL-2 RECEPTORS ON TUMOR-INFILTRATING LYMPHOCYTES
    TRENTIN, L
    ZAMBELLO, R
    BULIAN, P
    CERUTTI, A
    MILANI, A
    PIRONE, E
    NITTI, D
    AGOSTINI, C
    SEMENZATO, G
    BRITISH JOURNAL OF CANCER, 1994, 69 (06) : 1046 - 1051
  • [7] Synergistic anti-tumor effect of glycosylphosphatidylinositol-anchored IL-2 and IL-12
    Ji, JF
    Li, JH
    Holmes, LM
    Burgin, KE
    Yu, XZ
    Wagner, TE
    Wei, YZ
    JOURNAL OF GENE MEDICINE, 2004, 6 (07): : 777 - 785
  • [8] Brain tumor treatment with IL-2 and IL-12 producing autologous cancer cell vaccines
    Desaknai, S
    Lumniczky, K
    Hidvegi, EJ
    Hamada, H
    Safrany, G
    PROGRESS IN BASIC AND CLINICAL IMMUNOLOGY, 2001, 495 : 369 - 372
  • [9] Anti-tumor Immunity Induced by Tumor Cells Expressing a Membrane-bound Form of IL-2 and SDF-1
    Choi, Jin Wha
    Lim, Ho Yong
    Chang, Mi-Ra
    Cheon, Ji-Yeon
    Kirn, Young Sang
    ANIMAL CELLS AND SYSTEMS, 2008, 12 (04) : 193 - 201
  • [10] IL-2 and IL-12 increase gene transduction by recombinant adenovirus into primary human lymphocytes.
    Di Nicola, M
    Bregni, M
    Milanesi, M
    Longoni, P
    Matteucci, P
    Siena, S
    Jordan, CT
    Gianni, AM
    BONE MARROW TRANSPLANTATION, 1998, 21 : S111 - S111
12345