Cinnamic acid hybrids as anticancer agents: A mini-review

被引：42
作者：
Feng, Lian-Shun [1 ]
Cheng, Jin-Bo [1 ]
Su, Wen-Qi [1 ]
Li, Hong-Ze [2 ]
Xiao, Tao [2 ]
Chen, De-An [1 ]
Zhang, Zhi-Liu [3 ]
机构：
[1] WuXi AppTec Co Ltd, Wuhan 430074, Peoples R China
[2] WuXi AppTec Co Ltd, Chengdu, Peoples R China
[3] WuXi AppTec Co Ltd, Shanghai 200131, Peoples R China
来源：
ARCHIV DER PHARMAZIE | 2022年 / 355卷 / 07期
关键词：
anticancer; cinnamic acid; hybrids; mechanisms of action; structure-activity relationship; VIVO ANTITUMOR-ACTIVITY; IN-VITRO; BIOLOGICAL EVALUATION; GLYCYRRHETINIC ACIDS; DERIVATIVES; DESIGN; INHIBITORS; PROLIFERATION; ANTIOXIDANTS; POTENT;
D O I：
10.1002/ardp.202200052
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cancer, as a long-lasting and dramatic disease, affects almost one-third of human beings globally. Chemotherapeutics play an important role in cancer treatment, but multidrug resistance and severe adverse effects have already become the main causes of failure in tumor chemotherapy. Therefore, it is an urgent need to develop novel chemotherapeutics. Cinnamic acid contains a ubiquitous alpha,beta-unsaturated acid moiety presenting potential therapeutic effects in the treatment of cancer as these derivatives could act on cancer cells by diverse mechanisms of action. Accordingly, cinnamic acid derivatives are critical scaffolds in discovering novel anticancer agents. This review provides a comprehensive overview of cinnamic acid hybrids as anticancer agents. The structure-activity relationship, as well as the mechanisms of action, are also discussed, covering articles published from 2012 to 2021.
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页数：8
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