New cannabidiol (CBD) derivatives: Synthesis, anti-inflammatory activity, and molecular docking

被引：10

作者：

Zi, Cheng-Ting ^{[1
]}

Xie, Yin-Rong ^{[1
,2
]}

Niu, Yun ^{[1
,2
]}

Liu, Zhen-Hao ^{[1
,2
]}

Yang, Liu ^{[3
]}

Xi, Yong -Kai ^{[1
]}

Li, Zhen-Jie ^{[4
]}

Zhang, Feng-Mei ^{[4
]}

Xiang, Ze-Min ^{[1
,2
]}

Sheng, Jun ^{[1
,2
]}

机构：

[1] Yunnan Agr Univ, Coll Sci, Key Lab Puer Tea Sci, Minist Educ, Kunming 650201, Peoples R China

[2] Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Chi, Kunming 650201, Peoples R China

[4] R&D Ctr China Tobacco Yunnan Ind Co Ltd, Yunnan Key Lab Tobacco Chem, Kunming 650231, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2022年 / 51卷

关键词：

Cannabidiol(CBD); Synthesis; Anti-inflammatory activity; Molecular docking; Solubility; INFLAMMATION; THERAPY; ALPHA;

D O I：

10.1016/j.phytol.2022.08.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A series of new cannabidiol (CBD) derivatives were synthesized by employing hydrogenation reaction and click chemistry. Then, the cytotoxicity and anti-inflammatory activities of cannabinoid derivatives were determined. Compound 14 was found to have low cytotoxicity and high anti-inflammatory activity, and the anti-inflammatory mechanism of compound 14 was preliminarily explored, which inhibited the synthesis and release of the pro-inflammatory cytokine TNF-alpha. The experimental results were confirmed by docking analysis. The water solubility of compound 14 was determined. Based on the results, the structure-activity relationships (SARs) of the CBD derivatives were discussed for exploring novel anti-inflammatory drugs.

引用

页码：97 / 103

页数：7

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