LPS/TLR4 signal transduction pathway

被引：2553
|
作者：
Lu, Yong-Chen [1 ,2 ]
Yeh, Wen-Chen [1 ,2 ]
Ohashi, Pamela S. [1 ,2 ,3 ]
机构：
[1] Ontario Canc Inst, Campbell Family Inst Breast Canc Res, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2C1, Canada
[3] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada
来源：
CYTOKINE | 2008年 / 42卷 / 02期
关键词：
toll-like receptor; LPS; proinflammatory cytokines; MyD88; TRIF;
D O I：
10.1016/j.cyto.2008.01.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：145 / 151
页数：7
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