Recent advance in the synthesis of (1,1-difluoroethyl)arenes

被引：13

作者：

Li, Xinjin ^{[1
]}

Liu, Jianchang ^{[1
]}

Li, Xiangye ^{[1
]}

Liu, Hefu ^{[1
]}

Liu, Hui ^{[1
]}

Li, Yueyun ^{[1
]}

Liu, Yuying ^{[1
]}

Dong, Yunhui ^{[1
]}

机构：

[1] Shandong Univ Technol, Coll Chem & Chem Engn, 266 West Xincun Rd, Zibo 255000, Peoples R China

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2018年 / 216卷

关键词：

Fluorinated compounds; 1,1-Difluoroethylation; Arenes; Difluoromethylene; Synthetic methods; GEM-DIFLUORO COMPOUNDS; REGIOSELECTIVE SYNTHESIS; OXIDATIVE ACTIVATION; REAGENT; ACIDS; 1,1-DIFLUOROETHYLATION; ALDEHYDES; FLUORIDE; KETONES;

D O I：

10.1016/j.jfluchem.2018.10.011

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The introduction of fluorine atoms into an organic molecule has become an important research field since fluorinated compounds play crucial roles in life science and materials chemistry. Among various fluorinated moieties, the difluoroethyl group (CF2CH3) mimics the steric and electronic features of a methoxy group, and this modification can often bring about many beneficial effects to the target molecules. This feature article summarizes the presently known methods for the synthesis of (1,1-difluoroethyl)arenes, including nucleophilic, electrophilic, and free radical fluorination or 1,1-difluoroethylation reactions.

引用

页码：102 / 106

页数：5

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