Acujoint™, a highly efficient formulation with natural bioactive compounds, exerts potent anti-arthritis effects in human osteoarthritis - A pilot randomized double blind clinical study compared to combination of glucosamine and chondroitin

The aim of the study was to evaluate the efficacy and safety of Acujoint (TM) - a supplement for articular cartilage degradation- in the treatment of patients with Osteoarthritis (OA) by comparing it with glucosamine and chondroitin formulation, which is a popular supplement used to treat OA. Acujoint (TM) is a health supplement prepared with extracts of 3-O-acetyl-11-keto-beta-boswellic acid from Boswellia serrata, beta-Caryophyllene from Piper nigrum, aqueous extract of Kaempferia galangal and Cureit (TM) - a bioavailable curcumin formulation- in a fixed ratio based on complete natural matrix, which has been used to treat osteoarthritis. A randomized, double blind, active controlled, single centre, clinical study was carried out using Acujoint (TM) during 90 days of treatment in 24 patients (1:1 ratio) with symptoms of moderate to mild OA along with combination of Glucosamine (1500 mg) and Chondroitin (1200 mg). The study shows that Acujoinr" can provide significant improvement in relieving the symptoms and the pain associated with active OA between the groups as well as within the groups. Active OA patients, who received Acujoint (TM) at 250 mg per day for a treatment period of 90 days, reported statistically significant changes/decreases in their clinical symptoms and pain. This was evident from significant changes in the total Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) score, pain score, functional ability score, visual analog scale (VAS) score and Lequesne functional index values at P < 0.05 level. Acujoint (TM) promises beneficial effects for the treatment of human knee osteoarthritis by controlling inflammatory responses as well as the pain without any adverse effects.