Recent advances in the management of lung cancer

被引:334
作者
Jones, Gavin S. [1 ]
Baldwin, David R. [2 ,3 ]
机构
[1] Univ Nottingham, Div Epidemiol & Publ Hlth, Nottingham, England
[2] Univ Nottingham, Div Epidemiol & Publ Hlth, Med, Nottingham, England
[3] Nottingham Univ Hosp, Dept Resp Med, David Evans Bldg,City Campus, Nottingham NG5 1PB, England
关键词
Lung cancer; curative treatment; targeted therapies; early diagnosis; lung cancer management; ASSISTED THORACOSCOPIC SURGERY; RADIOFREQUENCY ABLATION; PALLIATIVE CARE; MULTICENTER; ADRENALECTOMY; METASTASES; OUTCOMES; TRIAL; CHEMOTHERAPY; GEFITINIB;
D O I
10.7861/clinmedicine.18-2-s41
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Historically, the prognosis for individuals diagnosed with lung cancer has been bleak. However, the past 10 years have seen important advances in treatment and diagnosis which have translated into the first improvements seen in lung cancer survival. This review highlights the major advances in treatments with curative intent, systemic targeted therapies, palliative care and early diagnosis in lung cancer. We discuss the pivotal research that underpins these new technologies/strategies and their current position in clinical practice.
引用
收藏
页码:S41 / S46
页数:6
相关论文
共 37 条
[1]   Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening [J].
Aberle, Denise R. ;
Adams, Amanda M. ;
Berg, Christine D. ;
Black, William C. ;
Clapp, Jonathan D. ;
Fagerstrom, Richard M. ;
Gareen, Ilana F. ;
Gatsonis, Constantine ;
Marcus, Pamela M. ;
Sicks, JoRean D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (05) :395-409
[2]   Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial [J].
Antonia, Scott J. ;
Lopez-Martin, Jose A. ;
Bendell, Johanna ;
Ott, Patrick A. ;
Taylor, Matthew ;
Eder, Joseph Paul ;
Jaeger, Dirk ;
Pietanza, M. Catherine ;
Le, Dung T. ;
de Braud, Filippo ;
Morse, Michael A. ;
Ascierto, Paolo A. ;
Horn, Leora ;
Amin, Asim ;
Pillai, Rathi N. ;
Evans, Jeffry ;
Chau, Ian ;
Bono, Petri ;
Atmaca, Akin ;
Sharma, Padmanee ;
Harbison, Christopher T. ;
Lin, Chen-Sheng ;
Christensen, Olaf ;
Calvo, Emiliano .
LANCET ONCOLOGY, 2016, 17 (07) :883-895
[3]   Early Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial [J].
Bakitas, Marie A. ;
Tosteson, Tor D. ;
Li, Zhigang ;
Lyons, Kathleen D. ;
Hull, Jay G. ;
Li, Zhongze ;
Dionne-Odom, J. Nicholas ;
Frost, Jennifer ;
Dragnev, Konstantin H. ;
Hegel, Mark T. ;
Azuero, Andres ;
Ahles, Tim A. .
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (13) :1438-1445
[4]  
Bargellini I, 2011, INSIGHTS IMAGING, V2, P567, DOI 10.1007/s13244-011-0110-7
[5]   Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].
Borghaei, H. ;
Paz-Ares, L. ;
Horn, L. ;
Spigel, D. R. ;
Steins, M. ;
Ready, N. E. ;
Chow, L. Q. ;
Vokes, E. E. ;
Felip, E. ;
Holgado, E. ;
Barlesi, F. ;
Kohlhaeufl, M. ;
Arrieta, O. ;
Burgio, M. A. ;
Fayette, J. ;
Lena, H. ;
Poddubskaya, E. ;
Gerber, D. E. ;
Gettinger, S. N. ;
Rudin, C. M. ;
Rizvi, N. ;
Crino, L. ;
Blumenschein, G. R. ;
Antonia, S. J. ;
Dorange, C. ;
Harbison, C. T. ;
Finckenstein, F. Graf ;
Brahmer, J. R. .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639
[6]  
Cancer Research UK, 2014, BE CLEAR CANC EV UPD
[7]  
Cancer Research UK, Lung Cancer Statistics
[8]   Radical Treatment of Non-Small-Cell Lung Cancer Patients with Synchronous Oligometastases Long-Term Results of a Prospective Phase II Trial (Nct01282450) [J].
De Ruysscher, Dirk ;
Wanders, Rinus ;
van Baardwijk, Angela ;
Dingemans, Anne-Marie C. ;
Reymen, Bart ;
Houben, Ruud ;
Bootsma, Gerben ;
Pitz, Cordula ;
van Eijsden, Linda ;
Geraedts, Wiel ;
Baumert, Brigitta G. ;
Lambin, Philippe .
JOURNAL OF THORACIC ONCOLOGY, 2012, 7 (10) :1547-1555
[9]   Percutaneous radiofrequency ablation of malignancies in the lung [J].
Dupuy, DE ;
Zagoria, RJ ;
Akerley, W ;
Mayo-Smith, WW ;
Kavanagh, PV ;
Safran, H .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2000, 174 (01) :57-59
[10]   Video-assisted thoracoscopic surgery versus open lobectomy for primary non-small-cell lung cancer: a propensity-matched analysis of outcome from the European Society of Thoracic Surgeon databaseaEuro [J].
Falcoz, Pierre-Emmanuel ;
Puyraveau, Marc ;
Thomas, Pascal-Alexandre ;
Decaluwe, Herbert ;
Huertgen, Martin ;
Petersen, Rene Horsleben ;
Hansen, Henrik ;
Brunelli, Alessandro .
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2016, 49 (02) :602-609